KANSL2 - KAT8 regulatory NSL complex subunit 2 Gene

Also Known as NSL2; C12orf41

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54934

About KANSL2

Cytogenetic location: 12q13.11 Genomic coordinates (GRCh38): 12:48,653,211-48,682,238 (from NCBI)

This gene has 15 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in bone marrow (RPKM 25.9), testis (RPKM 12.9) and 25 other tissues.

Summary

Involved in histone H4-K16 acetylation; histone H4-K5 acetylation; and histone H4-K8 acetylation. Located in several cellular components, including actin cytoskeleton; cytosol; and nucleoplasm. Part of Histone Acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

KANSL2 Products (1)

mRNA	Protein	Name
NM_017822.4	NP_060292.3	KAT8 regulatory NSL complex subunit 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24788516	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of NSL complex	IDA IDA: Inferred from direct assay	20018852	GOA
part of histone acetyltransferase complex	IDA IDA: Inferred from direct assay	20018852	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KANSL2 Protein Structure

zf-C3Hc3H

0
100
200
300
400
492 a.a.

Protein Preferred Names	Protein Names
KAT8 regulatory NSL complex subunit 2	NSL complex protein NSL2

KANSL2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KANSL2	Q9H9L4	WDR5	Homo sapiens	P61964	GMS	24788516
Intra	KANSL2	Q9H9L4	WDR5	Homo sapiens	P61964	ITC	24788516

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Koolen-De Vries Syndrome	KDVS 17q21.31 Microdeletion Syndrome Microdeletion 17q21.31 Syndrome Chromosome 17q21.31 Deletion Syndrome Koolen De Vries Syndrome Kansl1-Related Intellectual Disability Syndrome Chromosome 17q21.31 Microdeletion Syndrome Monosomy 17q21.31 17q21.31 Deletion Syndrome Koolen Syndrome Del(17)(Q21.31)
Heinz Body Anemias	Heinz Body Anemia Heinz Body Anemias, Alpha- HEIBAN Anemia, Heinz Body Acquired Heinz Body Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07068	KANSL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KANSL2	VGNC	VGNC:73910
Bos taurus	KANSL2	VGNC	VGNC:30394
Rattus norvegicus	KANSL2	RGD	RGD:1303127
Canis familiaris	KANSL2	VGNC	VGNC:42205
Felis catus	KANSL2	VGNC	VGNC:63020
Mus musculus	KANSL2	MGD	MGI:1916862
Others	KANSL2	NCBI