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Cat. No.: HY-161123

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WDR5-IN-8

WDR5-IN-8 is a WDR5 inhibitor with IC₅₀ value of 15.5 nM. WDR5-IN-8 shows good anti-proliferative activity in two human acute leukemia cell lines. WDR5-IN-8 has antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 3033259-97-8
Formula: C₂₉H₂₉ClN₄O₂
Molecular Weight:501.02

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

WDR5-IN-8 Chemical Structure

CAS No.: 3033259-97-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

WDR5-IN-8 is a WDR5 inhibitor with IC₅₀ value of 15.5 nM. WDR5-IN-8 shows good anti-proliferative activity in two human acute leukemia cell lines. WDR5-IN-8 has antitumor activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
K562	IC₅₀	7.1 μM Compound: 20	Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 5 days by CCK-8 assay Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 5 days by CCK-8 assay	[PMID: 38166388]
MV4-11	IC₅₀	5.7 μM Compound: 20	Antiproliferative activity against human MV4-11 cells harboring MLL-r assessed as cell growth inhibition incubated for 5 days by CCK-8 assay Antiproliferative activity against human MV4-11 cells harboring MLL-r assessed as cell growth inhibition incubated for 5 days by CCK-8 assay	[PMID: 38166388]

Chemical Information

CAS No. 3033259-97-8
Molecular Weight 501.02
Formula C₂₉H₂₉ClN₄O₂
SMILES

CC1=C(C2=C(C3=CC(NCC4=C(NC=N4)C)=C2)CCN(C3=O)CC5=CC=C(C=C5)Cl)C=C(CO)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Qin S, et al. Discovery and Optimization of WDR5 Inhibitors via Cascade Deoxyribonucleic Acid-Encoded Library Selection Approach. J Med Chem. 2024 Jan 3. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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