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NCOA6 - nuclear receptor coactivator 6 Gene

Also Known as NRC; AIB3; ASC2; PRIP; TRBP; RAP250

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23054

About NCOA6

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:34,714,774-34,825,651 (from NCBI)

This gene has 9 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in testis (RPKM 8.8), thyroid (RPKM 7.4) and 25 other tissues.

Summary

The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]

NCOA6 Products (3)

mRNA	Protein	Name
NM_001242539.2	NP_001229468.1	nuclear receptor coactivator 6 isoform 2
NM_001318240.1	NP_001305169.1	nuclear receptor coactivator 6 isoform 1
NM_014071.5	NP_054790.2	nuclear receptor coactivator 6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	12039952	GOA
enables nuclear receptor coactivator activity	IPI IPI: Inferred from physical interaction	11443112	GOA
enables nuclear thyroid hormone receptor binding	IDA IDA: Inferred from direct assay	11443112	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10866662	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	10567404	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within DNA damage response	IDA IDA: Inferred from direct assay	17500065	GOA
involved in DNA-templated transcription initiation	IDA IDA: Inferred from direct assay	10567404	GOA
involved in myeloid cell differentiation	IDA IDA: Inferred from direct assay	11302752	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11443112	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of MLL3/4 complex	IPI IPI: Inferred from physical interaction	23508102	GOA
part of histone methyltransferase complex	IDA IDA: Inferred from direct assay	17500065	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11443112	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCOA6 Protein Structure

Nucleic_acid_bd

0
400
800
1200
1600
2063 a.a.

Protein Preferred Names	Protein Names
nuclear receptor coactivator 6	NRC RAP250

NCOA6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NCOA6	Q14686	KMT2C	Homo sapiens	Q8NEZ4	Anti Bait CoIP	12482968
Intra	NCOA6	Q14686	KMT2C	Homo sapiens	Q8NEZ4	Anti Bait CoIP	19433796
Intra	NCOA6	Q14686	KMT2C	Homo sapiens	Q8NEZ4	Anti Bait CoIP	23870121
Intra	NCOA6	Q14686	KMT2C	Homo sapiens	Q8NEZ4	Anti Bait CoIP	19047629
Intra	NCOA6	Q14686	TP53BP1	Homo sapiens	Q12888	Anti Bait CoIP	19433796
Intra	NCOA6	Q14686	ASH2L	Homo sapiens	Q9UBL3	Anti Bait CoIP	12482968
Intra	NCOA6	Q14686	ASH2L	Homo sapiens	Q9UBL3	Anti Bait CoIP	23870121
Intra	NCOA6	Q14686	ASH2L	Homo sapiens	Q9UBL3	Anti Bait CoIP	17500065
Intra	NCOA6	Q14686	ASH2L	Homo sapiens	Q9UBL3	Anti Bait CoIP	17925232
Intra	NCOA6	Q14686	ASH2L	Homo sapiens	Q9UBL3	Anti Bait CoIP	19433796
Intra	NCOA6	Q14686	ASH2L	Homo sapiens	Q9UBL3	Anti Bait CoIP	19047629
Intra	NCOA6	Q14686	WDR5	Homo sapiens	P61964	Anti Bait CoIP	19047629
Intra	NCOA6	Q14686	WDR5	Homo sapiens	P61964	Anti Bait CoIP	23870121
Intra	NCOA6	Q14686	WDR5	Homo sapiens	P61964	Anti Bait CoIP	17500065
Intra	NCOA6	Q14686	WDR5	Homo sapiens	P61964	Anti Bait CoIP	17925232
Intra	NCOA6	Q14686	WDR5	Homo sapiens	P61964	Anti Bait CoIP	19433796
Intra	NCOA6	Q14686	AR	Homo sapiens	P10275	Y2H	14645241
Intra	NCOA6	Q14686	AR	Homo sapiens	P10275	Anti Bait CoIP	14645241
Intra	NCOA6	Q14686	KMT2B	Homo sapiens	Q9UMN6	Anti Bait CoIP	19047629
Intra	NCOA6	Q14686	KMT2B	Homo sapiens	Q9UMN6	Anti Bait CoIP	19433796
Intra	NCOA6	Q14686	TP53BP1	Homo sapiens	Q12888-1	Pull Down	19433796

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Arthrogryposis, Distal, Type 7	Hecht Syndrome Trismus-Pseudocamptodactyly Syndrome Distal Arthrogryposis Type 7 Dutch-Kentucky Syndrome DA7 Hecht-Beals Syndrome Mouth, Inability To Open Completely, And Short Finger-Flexor Tendons Mouth, Inability To Completely Open, And Short Finger-Flexor Tendons Arthrogryposis Distal Type 7 Trismus Pseudocamptodactyly Syndrome Arthrogryposis, Distal, 7
Kabuki Syndrome 1	Kabuki Syndrome Niikawa-Kuroki Syndrome Kabuki Make-Up Syndrome Kms KABUK1 Kabuki Make Up Syndrome Nks Kabuki Makeup Syndrome Kabuki Syndrome, Type 1
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09094	NCOA6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20060	Ncoa6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26564	Ncoa6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NCOA6	VGNC	VGNC:82194
Bos taurus	NCOA6	VGNC	VGNC:31924
Felis catus	NCOA6	VGNC	VGNC:63742
Canis familiaris	NCOA6	VGNC	VGNC:43663
Mus musculus	NCOA6	MGD	MGI:1929915
Rattus norvegicus	NCOA6	RGD	RGD:620111
Others	NCOA6	NCBI