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Cat. No.: HY-153728

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WM-586

1 Cited Publications

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WM-586 is a covalent WDR5 inhibitor. WM-586 specifically decreases WDR5 and MYC interaction with an IC₅₀ of 101 nM. WM-586 is used in research on a variety of cancers including neuroblastoma, breast cancer, bladder cancer and colorectal cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 98.71%
CAS No.: 2894832-05-2
Formule: C₂₀H₂₀F₃N₅O₃S
Masse moléculaire:467.46

Stockage:

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

WM-586 Chemical Structure

CAS No.: 2894832-05-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Pureté et documentation
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Activité biologique

Description

IC₅₀ & Target

IC50: 101 nM (WDR5 and MYC interaction)^[1]

In Vitro

WM-586 specifically reduces the interaction between WDR5 and MYC with an IC₅₀ of 101 nM^[1].
WM-586 (0.5-30 μM) does not affect the binding of WDR5 to RBBP5^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2894832-05-2
Appearance Solid
Masse moléculaire 467.46
Formule C₂₀H₂₀F₃N₅O₃S
Color White to light yellow
SMILES

FC1=C(C[C@H](CCCC)C(NC2=NN=NN2)=O)C(F)=CC(C3=CC(S(F)(=O)=O)=CC=C3)=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Publications (1)

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bioRxiv

SAGA/ATAC complexes sustain aberrant chromatin regulation and promote tumorigenesis in diffuse midline glioma. [Abstract]

2026 Jan 23:2026.01.22.701194. PMID: 41648478

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ding J, et al. Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction. ACS Chem Biol. 2023 Jan 20;18(1):34-40. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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WM-586

1 Cited Publications

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Activité biologique
- Description
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- In Vitro
Chemical Information
Publications (1)
Pureté et documentation
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WM-586

MCE Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) WM-586

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WM-586

MCE Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) WM-586

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WM-586 Related Classifications

HY-153728 Related Classifications