WDHD1 - WD repeat and HMG-box DNA binding protein 1 Gene

Homo sapiens

Also known as AND1; CTF4; AND-1; CHTF4

Gene ID: 11169 | Gene type: protein coding

About WDHD1

Cytogenetic location: 14q22.2-q22.3 Genomic coordinates (GRCh38): 14:54,938,949-55,027,099 (from NCBI)

This gene has 5 transcripts (splice variants) and 212 orthologues. Broad expression in testis (RPKM 3.1), lymph node (RPKM 2.6) and 23 other tissues.

Summary

The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and Cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

WDHD1 Products(2)

mRNA	Protein	Name
NM_001008396.3	NP_001008397.1	WD repeat and HMG-box DNA-binding protein 1 isoform 2
NM_007086.4	NP_009017.1	WD repeat and HMG-box DNA-binding protein 1 isoform 1

WDHD1 Protein Structure

WD40

eIF2A

Mcl1_mid

HMG_box

0
200
400
600
800
1000
1129 a.a.

Protein Preferred Names

Protein Names

WD repeat and HMG-box DNA-binding protein 1

Acidic nucleoplasmic DNA-binding protein 1

Related Diseases

Diseases

Alias

Warsaw Breakage Syndrome

WABS

WBRS

Roberts-Sc Phocomelia Syndrome

Roberts Syndrome	Sc Phocomelia Syndrome
RBS	Long Bone Deficiencies Associated With Cleft Lip-Palate
Sc Pseudothalidomide Syndrome	Appelt-Gerken-Lenz Syndrome
Pseudothalidomide Syndrome	Tetraphocomelia-Cleft Palate Syndrome
Hypomelia Hypotrichosis Facial Hemangioma Syndrome	Roberts Syndrome/Sc Phocomelia
Roberts Tetraphocomelia Syndrome	Sc Syndrome
Sc Phocomelia	Sc Disease
Sc	Hemoglobin Sc Disease

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15758	WDHD1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	WDHD1	VGNC	VGNC:80782
Mus musculus	WDHD1	MGD	MGI:2443514
Macaca mulatta	WDHD1	VGNC	VGNC:79376
Rattus norvegicus	WDHD1	RGD	RGD:1310200
Bos taurus	WDHD1	VGNC	VGNC:36878
Canis familiaris	WDHD1	VGNC	VGNC:48347
Others	WDHD1	NCBI

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