WDHD1 - WD repeat and HMG-box DNA binding protein 1 Gene

Also Known as AND1; CTF4; AND-1; CHTF4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11169

About WDHD1

Cytogenetic location: 14q22.2-q22.3 Genomic coordinates (GRCh38): 14:54,938,949-55,027,099 (from NCBI)

This gene has 5 transcripts (splice variants) and 212 orthologues. Broad expression in testis (RPKM 3.1), lymph node (RPKM 2.6) and 23 other tissues.

Summary

The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and Cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

WDHD1 Products (2)

mRNA	Protein	Name
NM_001008396.3	NP_001008397.1	WD repeat and HMG-box DNA-binding protein 1 isoform 2
NM_007086.4	NP_009017.1	WD repeat and HMG-box DNA-binding protein 1 isoform 1

WDHD1 Protein Structure

WD40

eIF2A

Mcl1_mid

HMG_box

0
200
400
600
800
1000
1129 a.a.

Protein Preferred Names	Protein Names
WD repeat and HMG-box DNA-binding protein 1	Acidic nucleoplasmic DNA-binding protein 1

WDHD1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WDHD1	O75717	KAT2A	Homo sapiens	Q92830	Anti Tag CoIP	21725360
Intra	WDHD1	O75717	KAT2A	Homo sapiens	Q92830	Confocal	21725360

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Warsaw Breakage Syndrome	WABS WBRS
Roberts-Sc Phocomelia Syndrome	Roberts Syndrome Sc Phocomelia Syndrome RBS Long Bone Deficiencies Associated With Cleft Lip-Palate Sc Pseudothalidomide Syndrome Appelt-Gerken-Lenz Syndrome Pseudothalidomide Syndrome Tetraphocomelia-Cleft Palate Syndrome Hypomelia Hypotrichosis Facial Hemangioma Syndrome Roberts Syndrome/Sc Phocomelia Roberts Tetraphocomelia Syndrome Sc Syndrome Sc Phocomelia Sc Disease Sc Hemoglobin Sc Disease
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15758	WDHD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22919	Wdhd1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29433	Wdhd1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	WDHD1	VGNC	VGNC:80782
Mus musculus	WDHD1	MGD	MGI:2443514
Macaca mulatta	WDHD1	VGNC	VGNC:79376
Rattus norvegicus	WDHD1	RGD	RGD:1310200
Bos taurus	WDHD1	VGNC	VGNC:36878
Canis familiaris	WDHD1	VGNC	VGNC:48347
Others	WDHD1	NCBI