TADA2B - transcriptional adaptor 2B Gene

Also Known as ADA2B; ADA2(beta)

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 93624

About TADA2B

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:7,043,372-7,057,952 (from NCBI)

This gene has 5 transcripts (splice variants), 214 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 8.1), testis (RPKM 7.9) and 25 other tissues.

Summary

TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of Histone Acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]).[supplied by OMIM, Apr 2010]

TADA2B Products (1)

mRNA	Protein	Name
NM_152293.3	NP_689506.2	transcriptional adapter 2-beta

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	29232376	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SAGA-type complex	IDA IDA: Inferred from direct assay	18838386	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TADA2B Protein Structure

ZZ

Myb_DNA-binding

0
100
200
300
400
420 a.a.

Protein Preferred Names	Protein Names
transcriptional adapter 2-beta	ADA2-beta

TADA2B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TADA2B	Q86TJ2	AATF	Homo sapiens	Q9NY61	Y2H	29232376

Cross: Cross-species interaction Intra: Intraspecies interaction

TADA2B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810099	TADA2B Antibody (YA9443)	WB, IP	human

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia 7	Spinocerebellar Ataxia Type 7 SCA7 Opca3 Opca Iii Olivopontocerebellar Atrophy Iii Opca With Retinal Degeneration Opca With Macular Degeneration And External Ophthalmoplegia Adca, Type Ii Autosomal Dominant Cerebellar Ataxia Type 2 Olivopontocerebellar Atrophy 3 Autosomal Dominant Cerebellar Ataxia, Type Ii Autosomal Dominant Cerebellar Ataxia Type Ii Adca2 Adcaii Ataxia With Pigmentary Retinopathy Cerebellar Syndrome-Pigmentary Maculopathy Syndrome Olivopontocerebellar Atrophy With Retinal Degeneration Spinocerebellar Ataxia-7 Ataxia, Spinocerebellar, Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14155	TADA2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TADA2B	VGNC	VGNC:107202
Mus musculus	TADA2B	MGD	MGI:3035274
Felis catus	TADA2B	VGNC	VGNC:65923
Rattus norvegicus	TADA2B	RGD	RGD:1561605
Canis familiaris	TADA2B	VGNC	VGNC:47071