PIK3CD - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Gene

Homo sapiens

Also known as APDS; PI3K; IMD14; p110D; IMD14A; IMD14B; ROCHIS; P110DELTA

Gene ID: 5293 | Gene type: protein coding

About PIK3CD

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:9,627,258-9,729,114 (from NCBI)

This gene has 23 transcripts (splice variants), 214 orthologues, 9 paralogues and is associated with 5 phenotypes. Broad expression in lymph node (RPKM 21.4), bone marrow (RPKM 20.0) and 22 other tissues.

Summary

Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound Ras. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]

PIK3CD Products(38)

mRNA	Protein	Name
XM_047422564.1	XP_047278520.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2
XM_047422556.1	XP_047278512.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
XM_006710687.3	XP_006710750.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
XM_047422561.1	XP_047278517.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2
NM_001350234.2	NP_001337163.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform 2
XM_047422567.1	XP_047278523.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3
XM_047422573.1	XP_047278529.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4
XM_047422563.1	XP_047278519.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2
XM_047422550.1	XP_047278506.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
XM_047422574.1	XP_047278530.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5
XM_024447663.2	XP_024303431.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2
XM_047422555.1	XP_047278511.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
XM_047422577.1	XP_047278533.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5
XM_047422565.1	XP_047278521.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2
XM_047422554.1	XP_047278510.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
XM_024447664.2	XP_024303432.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3
XM_006710689.3	XP_006710752.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
XM_047422575.1	XP_047278531.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5
XM_047422553.1	XP_047278509.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
XM_047422560.1	XP_047278516.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
XM_047422568.1	XP_047278524.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3
XM_047422580.1	XP_047278536.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X7
XM_047422589.1	XP_047278545.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X8
XM_047422571.1	XP_047278527.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4
XM_047422552.1	XP_047278508.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
XM_047422572.1	XP_047278528.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4
XM_047422576.1	XP_047278532.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5
XM_047422557.1	XP_047278513.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
XM_047422566.1	XP_047278522.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3
XM_047422551.1	XP_047278507.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
XM_047422558.1	XP_047278514.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
NM_001350235.1	NP_001337164.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform 3
XM_047422578.1	XP_047278534.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X6
XM_047422559.1	XP_047278515.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
XM_047422570.1	XP_047278526.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4
XM_047422569.1	XP_047278525.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3
XM_047422562.1	XP_047278518.1	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2
NM_005026.5	NP_005017.3	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform 1

PIK3CD Protein Structure

PI3K_p85B

PI3K_rbd

PI3K_C2

PI3Ka

PI3_PI4_kinase

0
200
400
600
800
1044 a.a.

Protein Preferred Names

Protein Names

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

PI3-kinase p110 subunit delta	PI3Kdelta
phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta short variant 8/20
phosphoinositide-3-kinase C	phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta
ptdIns-3-kinase subunit p110-delta

Related Diseases

Diseases

Alias

Chitayat Syndrome

CHYTS

Bronchomalacia

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Immunodeficiency 14b, Autosomal Recessive

IMD14B

Lymphoid Interstitial Pneumonia

Lip Disease	Lymphocytic Interstitial Pneumonia
Lip Diseases	LIP
Disease Of Lips

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Immunodeficiency 36

IMD36	Activated Phosphoinositide 3-Kinase Delta Syndrome 2
Immunodeficiency, Type 36

Cowden Syndrome

Cowden Disease	Multiple Hamartoma Syndrome
Cowden'S Disease	Lhermitte-Duclos Disease
Cd	Cs
Mham	Dysplastic Gangliocytoma Of Cerebellum
Cowden'S Syndrome	Hamartoma Syndrome, Multiple

Roifman-Chitayat Syndrome

Combined Immunodeficiency With Faciooculoskeletal Anomalies	ROCHIS
Combined Immunodeficiency, Facial Dysmorphism, Optic Nerve Atrophy, Skeletal Anomalies, And Developmental Delay	Roifman-Chitayat Syndrome, Digenic

Lymphopenia

Lymphocytopenia

Immune System Disease

Abnormality Of The Immune System	Immune System And Disorders
Immune System Diseases

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Acquired Hypogammaglobulinemia	Common Variable Immune Deficiency
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi

Cloves Syndrome	Clove Syndrome
Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi, And Skeletal/Spinal Abnormalities	Clove Syndrome, Somatic
Congenital Lipomatous Overgrowth - Vascular Malformation - Epidermal Nevi	Congenital Lipomatous Overgrowth-Vascular Malformation-Epidermal Nevi-Skeletal Anomaly Syndrome
Congenital Lipomatous Overgrowth-Vascular Malformation-Epidermal Nevi-Spinal Anomaly Syndrome	CLOVE
Congenital Lipomatous Overgrowth Vascular Malformations Epidermal Nevi And Skeletal/Spinal Abnormalities	Congenital Arteriovenous Malformation
Arteriovenous Hemangioma	Nevus
Melanocytic Nevus	Benign Melanocytic Nevus

Granulomatosis With Polyangiitis

GPA	Wegener Granulomatosis
Wegener Granulomatosis, Formerly	Midline Granulomatosis
Wg, Formerly	Necrotizing Respiratory Granulomatosis
Wg	Wegeners Granulomatosis
Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis

Immunodeficiency 14

Activated Pi3k-Delta Syndrome	Apds
Pasli Disease	Imd14
Senescent T-Cells-Lymphadenopathy-Immunodeficiency Syndrome Due To P110delta-Activating Mutation	P110 Delta-Activating Mutation Causing Senescent T Cells, Lymphadenopathy, And Immunodeficiency

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Cowden Syndrome 1

Pten Hamartoma Tumor Syndrome	Bannayan-Riley-Ruvalcaba Syndrome
Lhermitte-Duclos Disease	Bannayan-Zonana Syndrome
Phts	Riley-Smith Syndrome
Bzs	Ruvalcaba-Myhre-Smith Syndrome
Multiple Hamartoma Syndrome	Rmss
Brrs	Dysplastic Gangliocytoma Of The Cerebellum
CWS1	Cs
Cd	Mham
Pten Hamartoma Tumor Syndrome With Granular Cell Tumor	Macrocephaly Multiple Lipomas And Hemangiomata
Bannayan-Ruvalcaba-Riley Syndrome	Myhre-Riley-Smith Syndrome
LDD	Cerebelloparenchymal Disorder Vi
Hamartoma Syndrome, Multiple	Bbrs
Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata	Macrocephaly, Multiple Lipomas, And Hemangiomata
Macrocephaly Pseudopapilledema And Multiple Hemangiomas	Ruvalcaba -Myhre-Smith Syndrome
Ruvalcaba-Myhre Syndrome	Cowden Disease
Macrocephaly Pseudopapilledema And Multiple Hemangiomata	Cerebellar Granule Cell Hypertrophy And Megalencephaly
Cpd6	Lhermitte-Duclos Syndrome
Pten Hamartoma Tumor Syndromes	Cowden Syndrome, Type 1

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Short Syndrome

Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly, And Teething Delay	Aarskog-Ose-Pande Syndrome
Lipodystrophy, Partial, With Rieger Anomaly And Short Stature	Lipodystrophy-Rieger Anomaly-Diabetes Syndrome
Rieger Anomaly-Partial Lipodystrophy Syndrome	Partial Lipodystrophy With Rieger Anomaly And Short Stature
Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly And Teething Delay	Growth Retardation-Rieger Anomaly
Short Stature-Hyperextensibility-Rieger Anomaly-Teething Delay	SHORTS

Immunodeficiency 14a, Autosomal Dominant

Activated Pi3k-Delta Syndrome	Apds
P110-Delta-Activating Mutation Causing Senescent T Cells, Lymphadenopathy, And Immunodeficiency	Pasli
IMD14A	Immunodeficiency 14
P110δ-Activating Mutation Causing Senescent T Cells, Lymphadenopathy, And Immunodeficiency	Senescent T-Cells-Lymphadenopathy-Immunodeficiency Syndrome Due To P110delta-Activating Mutation
Activated Pi3k-Delta Immunodeficiency Syndrome

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Mantle Cell Lymphoma

Lymphoma, Mantle Cell	Lcm
Mcl	Mantle Zone Lymphoma
Lymphoma Mantle-Cell	Lymphoma, Mantle-Cell
Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse	Malignant Lymphoma - Lymphocytic, Intermediate Differentiation
Diffuse Small Cleaved-Cell Lymphoma	Diffuse Small Cleaved Cell Malignant Lymphoma
Small Cleaved Cell Non-Hodgkin Lymphoma	Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma
Malignant Lymphomatous Polyposis	Malignant Small Cell, Noncleaved, Diffuse Lymphoma
Malignant Undifferentiated Cell, Non-Burkitt Lymphoma	Cleaved Cell Lymphoma
Small Cell Mantle Cell Lymphoma	Small Cleaved Cell Malignant Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-161366	OMS14	Inhibitor	/	Unkown
HY-RS10529	PIK3CD Human Pre-designed siRNA Set A		/	Unkown
HY-RS10530	Pik3cd Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS10531	Pik3cd Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PIK3CD	VGNC	VGNC:32891
Felis catus	PIK3CD	VGNC	VGNC:68856
Rattus norvegicus	PIK3CD	RGD	RGD:1310990
Mus musculus	PIK3CD	MGD	MGI:1098211
Macaca mulatta	PIK3CD	VGNC	VGNC:75997
Canis familiaris	PIK3CD	VGNC	VGNC:44557

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