Tgfb1i1 - transforming growth factor beta 1 induced transcript 1 Gene

Also Known as Hic5; ARA55; TSC-5; hic-5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21804

Summary

Predicted to enable several functions, including I-SMAD binding activity; Roundabout binding activity; and Androgen Receptor binding activity. Acts upstream of or within several processes, including epithelial cell differentiation; morphogenesis of embryonic epithelium; and negative regulation of fat cell differentiation. Located in focal adhesion. Is expressed in several structures, including bronchus; central nervous system; genitourinary system; heart; and vertebral axis musculature. Orthologous to human TGFB1I1 (transforming growth factor beta 1 induced transcript 1). [provided by Alliance of Genome Resources, Apr 2022]

Tgfb1i1 Products (4)

mRNA Protein Name
NM_001289550.1 NP_001276479.1 transforming growth factor beta-1-induced transcript 1 protein isoform a
NM_001289551.1 NP_001276480.1 transforming growth factor beta-1-induced transcript 1 protein isoform b
NM_001289552.1 NP_001276481.1 transforming growth factor beta-1-induced transcript 1 protein isoform c
NM_001289553.1 NP_001276482.1 transforming growth factor beta-1-induced transcript 1 protein isoform d

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9756887 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell fate commitment IGI
IGI: Inferred from genetic interaction
15687259 MGI
acts upstream of or within epithelial cell differentiation IGI
IGI: Inferred from genetic interaction
15687259 MGI
acts upstream of fat cell differentiation IGI
IGI: Inferred from genetic interaction
15687259 MGI
acts upstream of or within morphogenesis of embryonic epithelium IMP
IMP: Inferred from mutant phenotype
15687259 MGI
acts upstream of or within negative regulation of fat cell differentiation IGI
IGI: Inferred from genetic interaction
15687259 MGI
Cellular Component GO Annotation Evidence References Source
located in focal adhesion IDA
IDA: Inferred from direct assay
11784865 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transforming growth factor beta-1-induced transcript 1 protein

  • TGF beta-stimulated clone 5

  • androgen receptor-associated protein of 55 kDa

  • hydrogen peroxide-inducible clone 5 protein

Tgfb1i1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Tgfb1i1 Q62219 Plekhh2 Mus musculus Q8C115
Y2H
22832517
Cross
Tgfb1i1 Q62219 PTK2 Homo sapiens Q05397
Pull Down
9756887
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14438 TGFB1I1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tgfb1i1 NCBI NCBI:7041