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Calm2 - calmodulin 2 Gene

Also Known as Cam; Cam2; Camb; CaMII

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 50663

Summary

Enables several functions, including enzyme binding activity; nitric-oxide synthase regulator activity; and transmembrane transporter binding activity. Involved in several processes, including activation of Adenylate Cyclase activity; regulation of calcium ion transmembrane transporter activity; and regulation of vesicle-mediated transport. Located in several cellular components, including growth cone; myelin sheath; and nucleus. Colocalizes with mitochondrial membrane and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia 4; long QT syndrome 14; and long QT syndrome 15. Orthologous to several human genes including CALM1 (Calmodulin 1). [provided by Alliance of Genome Resources, Apr 2022]

Calm2 Products (1)

mRNA	Protein	Name
NM_017326.3	NP_059022.1	calmodulin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	15628869	RGD
enables nitric-oxide synthase binding	IDA IDA: Inferred from direct assay	20529840	RGD
enables nitric-oxide synthase regulator activity	IDA IDA: Inferred from direct assay	20529840	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11323678	RGD
enables transmembrane transporter binding	IDA IDA: Inferred from direct assay	15628869	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in establishment of protein localization to membrane	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in establishment of protein localization to mitochondrial membrane	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in positive regulation of nitric-oxide synthase activity	IDA IDA: Inferred from direct assay	20529840	RGD
involved in regulation of high voltage-gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	18322004	RGD
involved in regulation of ryanodine-sensitive calcium-release channel activity	IDA IDA: Inferred from direct assay	15628869	RGD
involved in regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	10854758	RGD
involved in response to corticosterone	IEP IEP: Inferred from expression pattern	16503919	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	22848456	RGD
located in growth cone	IDA IDA: Inferred from direct assay	7492944	RGD
located in mitochondrial membrane	IMP IMP: Inferred from mutant phenotype	23792689	RGD
located in myelin sheath	IDA IDA: Inferred from direct assay	19855925	RGD
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	22848456	RGD
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	22848456	RGD
located in synaptic vesicle membrane	IMP IMP: Inferred from mutant phenotype	23792689	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
calmodulin-2	calmodulin 2 (phosphorylase kinase, delta)

Calm2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Calm1	P0DP29	Kcnn2	Rattus norvegicus	P70604	ITC	22579256
Intra	Calm1	P0DP29	Kcnn2	Rattus norvegicus	P70604	Fluorescence Spectr	22579256
Intra	Calm1	P0DP29	Kcnn2	Rattus norvegicus	P70604	Solution Sedimentation	22579256
Intra	Calm1	P0DP29	Kcnn2	Rattus norvegicus	P70604	X-Ray Diffraction	11323678
Intra	Calm1	P0DP29	Ppara	Rattus norvegicus	P37230	X-Ray Diffraction	18073110
Intra	Calm1	P0DP29	Ppara	Rattus norvegicus	P37230	Fluorescence Spectr	18073110
Intra	Calm1	P0DP29	Kcnn2	Rattus norvegicus	H6VQ94	Solution Sedimentation	22579256
Intra	Calm1	P0DP29	Kcnn2	Rattus norvegicus	H6VQ94	GMS	22579256
Intra	Calm1	P0DP29	Kcnn2	Rattus norvegicus	H6VQ94	ITC	22579256
Intra	Calm1	P0DP29	Kcnn2	Rattus norvegicus	H6VQ94	Fluorescence Spectr	22579256
Intra	Calm1	P0DP29	Kcnn2	Rattus norvegicus	H6VQ94	X-Ray Diffraction	22579256
Cross	Calm1	P0DP29	CEP290	Homo sapiens	O15078	Anti Tag CoIP	23446637
Cross	Calm1	P0DP29	ORAI1	Homo sapiens	Q96D31	Pull Down	19706428
Cross	Calm1	P0DP29	ORAI1	Homo sapiens	Q96D31	Anti Tag CoIP	19706428
Cross	Calm1	P0DP29	EGFR	Homo sapiens	P00533	Far-WB	11853560
Cross	Calm1	P0DP29	EGFR	Homo sapiens	P00533	Crosslink	11853560
Cross	Calm1	P0DP29	THOP1	Homo sapiens	P52888	Pull Down	19614740
Intra	Calm1	P0DP29	Thop1	Rattus norvegicus	P24155	SPR	22740335
Intra	Calm1	P0DP29	Cobl	Rattus norvegicus	D3ZUI5	Pull Down	26334624
Intra	Calm1	P0DP29	Cobl	Rattus norvegicus	D3ZUI5	Anti Bait CoIP	26334624
Intra	Calm1	P0DP29	Kcnq2	Rattus norvegicus	O88943	Anti Tag CoIP	22643219
Cross	Calm1	P0DP29	GRB7	Homo sapiens	Q14451	Far-WB	15806159
Cross	Calm1	P0DP29	SEC61A1	Canis familiaris	P38377	Peptide Array	21102557
Cross	Calm1	P0DP29	SEC61A1	Canis familiaris	P38377	FCS	21102557

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS26152	Calm2 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Calm2	NCBI	NCBI:805