KCNN2 - Kcnn2 potassium calcium-activated channel subfamily N member 2 Gene

Also Known as SK2; SKCa2; KCa2.2; SKCa 2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54262

Summary

Enables Calmodulin binding activity and small conductance calcium-activated Potassium Channel activity. Involved in positive regulation of potassium ion transport; potassium ion transport; and regulation of neuronal synaptic plasticity. Located in dendritic spine and neuronal cell body. Is integral component of membrane. Used to study essential tremor. Orthologous to human KCNN2 (potassium calcium-activated channel subfamily N member 2). [provided by Alliance of Genome Resources, Apr 2022]

KCNN2 Products (2)

mRNA Protein Name
NM_001309404.1 NP_001296333.1 small conductance calcium-activated potassium channel protein 2 isoform 1
NM_019314.2 NP_062187.1 small conductance calcium-activated potassium channel protein 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calmodulin binding IDA
IDA: Inferred from direct assay
9774106 RGD
enables calmodulin binding IMP
IMP: Inferred from mutant phenotype
18701069 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11323678 RGD
enables small conductance calcium-activated potassium channel activity IDA
IDA: Inferred from direct assay
8781233 RGD
enables small conductance calcium-activated potassium channel activity IMP
IMP: Inferred from mutant phenotype
14559917 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of potassium ion transport IMP
IMP: Inferred from mutant phenotype
28917524 RGD
involved in potassium ion transport IDA
IDA: Inferred from direct assay
11323678 RGD
involved in regulation of neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
21521760 RGD
Cellular Component GO Annotation Evidence References Source
located in dendritic spine IDA
IDA: Inferred from direct assay
21521760 RGD
located in membrane IDA
IDA: Inferred from direct assay
11323678 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15680700 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

small conductance calcium-activated potassium channel protein 2

  • potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2

  • potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2

  • small conductance calcium-activated potassium channel protein 2-lik

KCNN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Kcnn2 P70604 Calm1 Rattus norvegicus P0DP29
X-Ray Diffraction
15130477
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07170 KCNN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens KCNN2 NCBI NCBI:3781