KCNN2 - potassium calcium-activated channel subfamily N member 2 Gene

Also Known as SK2; hSK2; DYT34; SKCA2; KCa2.2; NEDMAB; SKCa 2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3781

About KCNN2

Cytogenetic location: 5q22.3 Genomic coordinates (GRCh38): 5:114,055,978-114,496,496 (from NCBI)

This gene has 11 transcripts (splice variants), 141 orthologues, 3 paralogues and is associated with 2 phenotypes. Biased expression in adrenal (RPKM 4.9), liver (RPKM 3.5) and 8 other tissues.

Summary

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of Potassium Channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three Other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

KCNN2 Products (3)

mRNA	Protein	Name
NM_001372233.1	NP_001359162.1	small conductance calcium-activated potassium channel protein 2 isoform c
NM_021614.4	NP_067627.3	small conductance calcium-activated potassium channel protein 2 isoform a
NM_170775.3	NP_740721.1	small conductance calcium-activated potassium channel protein 2 isoform b

KCNN2 Protein Structure

SK_channel

Ion_trans_2

CaMBD

0
100
200
300
400
500
579 a.a.

Protein Preferred Names	Protein Names
small conductance calcium-activated potassium channel protein 2	apamin-sensitive small-conductance Ca2+-activated potassium channel

KCNN2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KCNN2	Q9H2S1	ACTN2	Homo sapiens	P35609	Y2H	19815520
Intra	KCNN2	Q9H2S1	ACTN2	Homo sapiens	P35609	Pull Down	19815520

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Neurodevelopmental Disorder With Or Without Variable Movement Or Behavioral Abnormalities	NEDMAB
Dystonia 34, Myoclonic	DYT34
Aceruloplasminemia	Cerebellar Ataxia Hypoceruloplasminemia Hemosiderosis, Systemic, Due To Aceruloplasminemia Familial Apoceruloplasmin Deficiency Hereditary Ceruloplasmin Deficiency Deficiency Of Ferroxidase Hypoceruloplasminemia, Hereditary Ceruloplasmin Deficiency Systemic Hemosiderosis Due To Aceruloplasminemia ACERULOP
Deafness, Autosomal Recessive 100	DFNB100 Autosomal Recessive Nonsyndromic Deafness 100 Autosomal Recessive Deafness 100 Deafness, Autosomal Recessive, 100
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07170	KCNN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KCNN2	RGD	RGD:2963
Felis catus	KCNN2	VGNC	VGNC:67927
Bos taurus	KCNN2	VGNC	VGNC:30484
Canis familiaris	KCNN2	VGNC	VGNC:42285
Mus musculus	KCNN2	MGD	MGI:2153182
Macaca mulatta	KCNN2	VGNC	VGNC:74003