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Cat. No.: HY-180480

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NSC 104999

NSC 104999 is a Grb7 SH2 domain binder with moderate affinity (K_d = 32.3 μM). NSC 104999 exhibits anticancer activity against breast cancer.

For research use only. We do not sell to patients.

CAS No.: 1118745-14-4
Formula: C₃₆H₄₂N₈O₄
Molecular Weight:650.77

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

NSC 104999 Chemical Structure

CAS No.: 1118745-14-4

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

NSC 104999 is a Grb7 SH2 domain binder with moderate affinity (K_d = 32.3 μM). NSC 104999 exhibits anticancer activity against breast cancer^[1].

IC₅₀ & Target

K_d = 32.3 μM (Grb7 SH2 domain)^[1]

All EGFR Isoforms :

Chemical Information

CAS No. 1118745-14-4
Molecular Weight 650.77
Formula C₃₆H₄₂N₈O₄
SMILES

O=C(C1=CC=C(C(NC2=CC(C3=NCCN3)=CC(C(NCCCC)=O)=C2)=O)C=C1)NC4=CC(C5=NCCN5)=CC(C(NCCCC)=O)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ambaye ND, et al. The discovery of phenylbenzamide derivatives as Grb7-based antitumor agents. ChemMedChem. 2013 Feb;8(2):280-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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NSC 104999

All EGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

NSC 104999 Related Classifications

HY-180480 Related Classifications