TRIM36 - tripartite motif containing 36 Gene

Also Known as ANPH; ANPH1; RNF98; HAPRIN; RBCC728

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55521

About TRIM36

Cytogenetic location: 5q22.3 Genomic coordinates (GRCh38): 5:115,124,772-115,180,294 (from NCBI)

This gene has 10 transcripts (splice variants), 209 orthologues, 80 paralogues and is associated with 1 phenotype. Biased expression in testis (RPKM 36.6), brain (RPKM 4.1) and 4 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

TRIM36 Products (5)

mRNA	Protein	Name
NM_001017397.2	NP_001017397.1	E3 ubiquitin-protein ligase TRIM36 isoform 2
NM_001017398.2	NP_001017398.1	E3 ubiquitin-protein ligase TRIM36 isoform 3
NM_001300752.2	NP_001287681.1	E3 ubiquitin-protein ligase TRIM36 isoform 4
NM_001300759.2	NP_001287688.1	E3 ubiquitin-protein ligase TRIM36 isoform 5
NM_018700.4	NP_061170.2	E3 ubiquitin-protein ligase TRIM36 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	28087737	GOA
involved in regulation of microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	28087737	GOA
involved in spindle organization	IMP IMP: Inferred from mutant phenotype	28087737	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	28087737	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM36 Protein Structure

zf-C3HC4

zf-B_box

fn3

SPRY

0
200
400
600
728 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase TRIM36	RING finger protein 98

TRIM36 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRIM36	Q9NQ86	EIF4A2	Homo sapiens	Q14240-2	Validated Y2H	25416956
Intra	TRIM36	Q9NQ86	EIF4A2	Homo sapiens	Q14240-2	Y2H Array	25416956
Intra	TRIM36	Q9NQ86	ZMAT2	Homo sapiens	Q96NC0	Y2H Prey Pooling	25416956
Intra	TRIM36	Q9NQ86	ZMAT2	Homo sapiens	Q96NC0	Validated Y2H	25416956
Intra	TRIM36	Q9NQ86	BTRC	Homo sapiens	Q9Y297	Y2H Prey Pooling	32296183
Intra	TRIM36	Q9NQ86	BTRC	Homo sapiens	Q9Y297	Validated Y2H	32296183
Intra	TRIM36	Q9NQ86	BTRC	Homo sapiens	Q9Y297	Y2H Array	32296183
Intra	TRIM36	Q9NQ86	GLRX3	Homo sapiens	O76003	Y2H Prey Pooling	32296183
Intra	TRIM36	Q9NQ86	GLRX3	Homo sapiens	O76003	Y2H Prey Pooling	25416956
Intra	TRIM36	Q9NQ86	GLRX3	Homo sapiens	O76003	Y2H Array	32296183
Intra	TRIM36	Q9NQ86	EIF4A2	Homo sapiens	Q14240	Y2H Prey Pooling	25416956
Intra	TRIM36	Q9NQ86	ZNF417	Homo sapiens	Q8TAU3	Y2H Array	25416956
Intra	TRIM36	Q9NQ86	TRAF3IP3	Homo sapiens	Q9Y228	Y2H Prey Pooling	25416956
Intra	TRIM36	Q9NQ86	TRAF3IP3	Homo sapiens	Q9Y228	Validated Y2H	25416956
Intra	TRIM36	Q9NQ86	TRAF3IP3	Homo sapiens	Q9Y228	Y2H Array	25416956
Intra	TRIM36	Q9NQ86	GRB7	Homo sapiens	Q14451	Y2H Prey Pooling	25416956
Intra	TRIM36	Q9NQ86	GRB7	Homo sapiens	Q14451	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

TRIM36 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811462	TRIM36 Antibody	WB	Human, Mouse
HY-P89626	TRIM36 Antibody (YA8970)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human

Related Diseases

Diseases	Alias
Anencephaly 1	ANPH1 Anph Isolated Anencephaly/Exencephaly Anencephalus
Anencephaly	Aprosencephaly Anencephalus Congenital Absence Of Brain Absence Of A Large Part Of The Brain And The Skull Anencephalia Anencephalic Monster Brain Absence Brain Agenesis Brain Aplasia Absent Brain Anencephalic Congenital Absence Of Cerebrum Congenital Hemicrania Incomplete Anencephaly
Non-Syndromic X-Linked Intellectual Disability 101	Mrx101 X-Linked Mental Retardation 101
Syndromic X-Linked Intellectual Disability Cabezas Type	Cabezas Syndrome Syndromic X-Linked Mental Retardation 15 Mental Retardation, X-Linked, Syndromic 15 Mrss Mrxs15 Mrxsc X-Linked Mental Retardation With Short Stature X-Linked Mental Retardation With Short Stature, Hypogonadism, And Abnormal Gait Mental Retardation, X-Linked, With Short Stature Mental Retardation, X-Linked, With Short Stature, Hypogonadism, And Abnormal Gait
Neuronopathy, Distal Hereditary Motor, Type Iid	HMN2D Hmn Iid Dhmn2d Distal Hereditary Motor Neuronopathy Type 2d Distal Hereditary Motor Neuropathy Type Iid Neuronopathy, Distal Hereditary Motor, Type 2d Neuropathy, Distal Hereditary Motor, Type Iid Spinal Muscular Atrophy, Distal, Autosomal Dominant, Calf-Predominant Distal Spinal Muscular Atrophy With Calf Predominance Neuronopathy, Distal Hereditary Motor, 2d Autosomal Dominant Spinal Muscular Atrophy Distal Calf-Predominant Dhmn Iid Neuropathy, Motor, Distal, Hereditary, Type 2d
Gait Apraxia
Distal Hereditary Motor Neuronopathy Type 2	Distal Hereditary Motor Neuropathy, Type Ii Distal Hereditary Motor Neuropathy Type 2 Distal Hereditary Motor Neuropathy Type Ii Hmn Ii Hmn2 Distal Hereditary Motor Neuronopathy, Type Ii Distal Spinal Muscular Atrophy Type 2 Dhmn2 Dsma2 Neuropathy, Motor, Distal, Hereditary, Type Ii Spinal Muscular Atrophy, Jerash Type
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15040	TRIM36 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRIM36	MGD	MGI:106264
Macaca mulatta	TRIM36	VGNC	VGNC:79023
Felis catus	TRIM36	VGNC	VGNC:66536
Canis familiaris	TRIM36	VGNC	VGNC:47817
Rattus norvegicus	TRIM36	RGD	RGD:1308714
Bos taurus	TRIM36	VGNC	VGNC:36331
Others	TRIM36	NCBI