TRIM36 - tripartite motif containing 36 Gene

Homo sapiens

Also known as ANPH; ANPH1; RNF98; HAPRIN; RBCC728

Gene ID: 55521 | Gene type: protein coding

About TRIM36

Cytogenetic location: 5q22.3 Genomic coordinates (GRCh38): 5:115,124,772-115,180,294 (from NCBI)

This gene has 10 transcripts (splice variants), 209 orthologues, 80 paralogues and is associated with 1 phenotype. Biased expression in testis (RPKM 36.6), brain (RPKM 4.1) and 4 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

TRIM36 Products(5)

mRNA	Protein	Name
NM_001017397.2	NP_001017397.1	E3 ubiquitin-protein ligase TRIM36 isoform 2
NM_001017398.2	NP_001017398.1	E3 ubiquitin-protein ligase TRIM36 isoform 3
NM_001300752.2	NP_001287681.1	E3 ubiquitin-protein ligase TRIM36 isoform 4
NM_001300759.2	NP_001287688.1	E3 ubiquitin-protein ligase TRIM36 isoform 5
NM_018700.4	NP_061170.2	E3 ubiquitin-protein ligase TRIM36 isoform 1

TRIM36 Protein Structure

zf-C3HC4

zf-B_box

fn3

SPRY

0
200
400
600
728 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase TRIM36

RING finger protein 98

Related Diseases

Diseases

Alias

Anencephaly 1

ANPH1	Anph
Isolated Anencephaly/Exencephaly	Anencephalus

Anencephaly

Aprosencephaly	Anencephalus
Congenital Absence Of Brain	Absence Of A Large Part Of The Brain And The Skull
Anencephalia	Anencephalic Monster
Brain Absence	Brain Agenesis
Brain Aplasia	Absent Brain
Anencephalic	Congenital Absence Of Cerebrum
Congenital Hemicrania	Incomplete Anencephaly

Non-Syndromic X-Linked Intellectual Disability 101

Mrx101

X-Linked Mental Retardation 101

Syndromic X-Linked Intellectual Disability Cabezas Type

Cabezas Syndrome	Syndromic X-Linked Mental Retardation 15
Mental Retardation, X-Linked, Syndromic 15	Mrss
Mrxs15	Mrxsc
X-Linked Mental Retardation With Short Stature	X-Linked Mental Retardation With Short Stature, Hypogonadism, And Abnormal Gait
Mental Retardation, X-Linked, With Short Stature	Mental Retardation, X-Linked, With Short Stature, Hypogonadism, And Abnormal Gait

Neuronopathy, Distal Hereditary Motor, Type Iid

HMN2D	Hmn Iid
Dhmn2d	Distal Hereditary Motor Neuronopathy Type 2d
Distal Hereditary Motor Neuropathy Type Iid	Neuronopathy, Distal Hereditary Motor, Type 2d
Neuropathy, Distal Hereditary Motor, Type Iid	Spinal Muscular Atrophy, Distal, Autosomal Dominant, Calf-Predominant
Distal Spinal Muscular Atrophy With Calf Predominance	Neuronopathy, Distal Hereditary Motor, 2d
Autosomal Dominant Spinal Muscular Atrophy Distal Calf-Predominant	Dhmn Iid
Neuropathy, Motor, Distal, Hereditary, Type 2d

Gait Apraxia

Distal Hereditary Motor Neuronopathy Type 2

Distal Hereditary Motor Neuropathy, Type Ii	Distal Hereditary Motor Neuropathy Type 2
Distal Hereditary Motor Neuropathy Type Ii	Hmn Ii
Hmn2	Distal Hereditary Motor Neuronopathy, Type Ii
Distal Spinal Muscular Atrophy Type 2	Dhmn2
Dsma2	Neuropathy, Motor, Distal, Hereditary, Type Ii
Spinal Muscular Atrophy, Jerash Type

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15040	TRIM36 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRIM36	MGD	MGI:106264
Macaca mulatta	TRIM36	VGNC	VGNC:79023
Felis catus	TRIM36	VGNC	VGNC:66536
Canis familiaris	TRIM36	VGNC	VGNC:47817
Rattus norvegicus	TRIM36	RGD	RGD:1308714
Bos taurus	TRIM36	VGNC	VGNC:36331

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