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LAX1 - lymphocyte transmembrane adaptor 1 Gene

Also Known as LAX

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54900

About LAX1

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:203,765,183-203,776,372 (from NCBI)

This gene has 3 transcripts (splice variants) and 97 orthologues. Biased expression in lymph node (RPKM 6.4), appendix (RPKM 5.1) and 13 other tissues.

Summary

Enables SH2 domain binding activity and protein kinase binding activity. Involved in several processes, including B cell activation; negative regulation of MAP kinase activity; and negative regulation of T cell activation. Located in Golgi apparatus; cytosol; and plasma membrane. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

LAX1 Products (3)

mRNA	Protein	Name
NM_001136190.2	NP_001129662.1	lymphocyte transmembrane adapter 1 isoform b
NM_001282878.1	NP_001269807.1	lymphocyte transmembrane adapter 1 isoform c
NM_017773.4	NP_060243.2	lymphocyte transmembrane adapter 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SH2 domain binding	IDA IDA: Inferred from direct assay	12359715	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12359715	GOA
enables protein kinase binding	IDA IDA: Inferred from direct assay	12359715	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in B cell activation	IDA IDA: Inferred from direct assay	12359715	GOA
involved in immune response	IDA IDA: Inferred from direct assay	12359715	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	12359715	GOA
involved in negative regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	12359715	GOA
involved in negative regulation of T cell activation	IDA IDA: Inferred from direct assay	12359715	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	12359715	GOA
NOT located in membrane raft	IDA IDA: Inferred from direct assay	12359715	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
lymphocyte transmembrane adapter 1	LAT-like membrane associated protein

LAX1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LAX1	Q8IWV1	STAMBPL1	Homo sapiens	Q96FJ0	Y2H Prey Pooling	25416956
Intra	LAX1	Q8IWV1	STAMBPL1	Homo sapiens	Q96FJ0	Y2H Array	25416956
Intra	LAX1	Q8IWV1	STAMBPL1	Homo sapiens	Q96FJ0	Validated Y2H	25416956
Intra	LAX1	Q8IWV1	GRB7	Homo sapiens	Q14451	Y2H Array	31515488
Intra	LAX1	Q8IWV1	GRB7	Homo sapiens	Q14451	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Rheumatic Pulmonary Valve Disease	Rheumatic Disease Of Pulmonary Valve Rheumatic Pulmonary Incompetence
Aortic Valve Insufficiency	Aortic Regurgitation Rheumatic Aortic Regurgitation Aortic Insufficiency Rheumatic Aortic Insufficiency Rheumatic Aortic Valve Insufficiency Aortic Incompetence Corrigan'S Disease Rheumatic Aortic Valve Regurgitation Aortic Valve Incompetency Ai - [Aortic Incompetence] Incompetent Aortic Valve Ar - [Aortic Regurgitation] Calcific Aortic Valve Regurgitation Myxomatous Aortic Valve Regurgitation Annular Incompetency Of Aortic Valve Austin Flint Murmur Flint Murmur Rheumatic Aortic Incompetence Rheumatic Ai - [Aortic Insufficiency]
Mitral Valve Insufficiency	Mitral Regurgitation Congenital Insufficiency Of Mitral Valve Congenital Mitral Insufficiency Congenital Mitral Regurgitation Mitral Valve Incompetence Mitral Valve Regurgitation Mr - [Mitral Regurgitation] Mi - [Mitral Incompetence] Mitral Valve Annular Incompetency Congenital Mitral Valve Incompetence Congenital Mitral Valve Insufficiency Congenital Mitral Valve Regurgitation Congenital Mitral Incompetence
Mitral Valve Disease	Chronic Rheumatic Mitral Valve Rheumatic Mitral Insufficiency Disease Of Mitral Valve Mitral Rh Valve Dis. Rheumatic Disease Of Mitral Valve Rheumatic Mitral Valve Changes Rheumatic Mitral Valve Incompetence Rheumatic Mitral Valve Regurgitation Abnormality Of The Mitral Valve Diseases Of Mitral Valve Rheumatic Mitral Regurgitation
Patent Foramen Ovale	Atrial Septal Defect Within Oval Fossa Foramen Ovale Patent Ostium Secundum Atrial Septal Defect Atrial Septal Defect, Ostium Secundum Type Foramen Ovale, Patent Defect, Patent Or Persistent, Ostium Secundum Ostium Secundum Type Atrial Septal Defect Persistent Ostium Secundum Asd Ostium Secundum Type Ostium Secundum Asd Osasd Asd, Ostium Secundum Type Pfo - [Patent Foramen Ovale] Open Foramen Ovale Open Oval Foramen Persistent Foramen Ovale Secundum Atrial Septal Defect

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07540	LAX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20760	Lax1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27273	Lax1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LAX1	RGD	RGD:1563522
Bos taurus	LAX1	VGNC	VGNC:30802
Mus musculus	LAX1	MGD	MGI:2443362
Felis catus	LAX1	VGNC	VGNC:107891
Macaca mulatta	LAX1	VGNC	VGNC:106401
Canis familiaris	LAX1	VGNC	VGNC:42600
Others	LAX1	NCBI