1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. Latanoprost acid

Latanoprost acid 

Cat. No.: HY-113756A
Handling Instructions

Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor. Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes.

For research use only. We do not sell to patients.

Latanoprost acid Chemical Structure

Latanoprost acid Chemical Structure

CAS No. : 41639-83-2

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Description

Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor[1]. Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes[2].

IC50 & Target[1]

FP

 

In Vitro

Latanoprost acid (10-20 μM;24 hours) reduces he protein expressions of c-fos and NFATc1[1].
Latanoprost acid (10μM with 50ng/ml RANKL) significantly inhibits ERK, p38, AKT and JNK[1].
Latanoprost acid (10 μM, 20 μM) significantly inhibits the mature osteoclast formation[1].

Western Blot Analysis[1]

Cell Line: Bone marrow-derived macrophages cells (BMMs)
Concentration: 10 μM, 20 μM
Incubation Time: 24 hours
Result: Reduced he protein expressions of c-fos and NFATc1.
In Vivo

Latanoprost acid (i.p.; 20 mg/kg; once a day for 7 days) notably prevents LPS-induced bone destruction at a dose of 20mg/kg[1].

Animal Model: 8-week-old C57BL/6J mice[1]
Dosage: 20 mg/kg
Administration: Intraperitoneally injected; once a day for 7 days
Result: Notably prevented LPS-induced bone destruction at a dose of 20mg/kg.
Molecular Weight

390.51

Formula

C₂₃H₃₄O₅

CAS No.

41639-83-2

SMILES

O[[email protected]@H]1[[email protected]@H]([[email protected]]([[email protected]@H](C1)O)CC[[email protected]](CCC2=CC=CC=C2)O)C/C=C\CCCC(O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Latanoprost acidProstaglandin ReceptorprostanoidFP-PGosteoclastgenesisERKAKTJNKp38c-fos/NFATc1pressureeyesInhibitorinhibitorinhibit

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Latanoprost acid
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