TNFAIP1 - TNF alpha induced protein 1 Gene

Also Known as B12; B61; EDP1; BTBD34; hBACURD2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7126

About TNFAIP1

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,335,761-28,347,009 (from NCBI)

This gene has 6 transcripts (splice variants), 223 orthologues and 2 paralogues. Ubiquitous expression in lung (RPKM 21.1), spleen (RPKM 20.2) and 25 other tissues.

Summary

This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]

TNFAIP1 Products (1)

mRNA Protein Name
NM_021137.5 NP_066960.1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19615732 GOA
enables small GTPase binding IDA
IDA: Inferred from direct assay
19637314 GOA
contributes to ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
19782033 GOA
Biological Process GO Annotation Evidence References Source
involved in cell migration IMP
IMP: Inferred from mutant phenotype
19782033 GOA
involved in immune response IEP
IEP: Inferred from expression pattern
1370465 GOA
involved in negative regulation of Rho protein signal transduction IMP
IMP: Inferred from mutant phenotype
19782033 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
19782033 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
19782033 GOA
involved in stress fiber assembly IMP
IMP: Inferred from mutant phenotype
19782033 GOA
Cellular Component GO Annotation Evidence References Source
part of Cul3-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
19782033 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
19637314 GOA
located in endosome IDA
IDA: Inferred from direct assay
19637314 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFAIP1 Protein Structure

BTB_2

BTB_2: BTB/POZ domain (30 - 120)

  • 0
  • 100
  • 200
  • 300
  • 316 a.a.
Protein Preferred Names Protein Names

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

  • BTB/POZ domain-containing protein TNFAIP1

TNFAIP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TNFAIP1 Q13829 CAPN7 Homo sapiens Q7Z479
Validated Y2H
25416956
Intra
TNFAIP1 Q13829 CAPN7 Homo sapiens Q7Z479
Y2H Array
25416956
Intra
TNFAIP1 Q13829 POLR1C Homo sapiens O15160
Validated Y2H
25416956
Intra
TNFAIP1 Q13829 POLR1C Homo sapiens O15160
Y2H
21988832
Intra
TNFAIP1 Q13829 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
TNFAIP1 Q13829 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
TNFAIP1 Q13829 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
TNFAIP1 Q13829 APOE Homo sapiens P02649
Y2H Pooling
32814053
Intra
TNFAIP1 Q13829 APOE Homo sapiens P02649
Validated Y2H
32814053
Intra
TNFAIP1 Q13829 APOE Homo sapiens P02649
Y2H Array
32814053
Intra
TNFAIP1 Q13829 CAPN7 Homo sapiens Q9Y6W3
Validated Y2H
32296183
Intra
TNFAIP1 Q13829 KCTD13 Homo sapiens Q8WZ19
Validated Y2H
25416956
Intra
TNFAIP1 Q13829 KCTD13 Homo sapiens Q8WZ19
Y2H Array
32296183
Intra
TNFAIP1 Q13829 KCTD13 Homo sapiens Q8WZ19
Y2H Prey Pooling
32296183
Intra
TNFAIP1 Q13829 CUL3 Homo sapiens Q13618
Validated Y2H
25416956
Intra
TNFAIP1 Q13829 KCTD13 Homo sapiens Q8WZ19
Anti Tag CoIP
33961781
Intra
TNFAIP1 Q13829 CUL3 Homo sapiens Q13618
Y2H Array
25416956
Intra
TNFAIP1 Q13829 KCTD13 Homo sapiens Q8WZ19
Validated Y2H
32296183
Intra
TNFAIP1 Q13829 KCTD10 Homo sapiens Q9H3F6
Validated Y2H
32296183
Intra
TNFAIP1 Q13829 KCTD10 Homo sapiens Q9H3F6
Y2H Prey Pooling
32296183
Intra
TNFAIP1 Q13829 KCTD10 Homo sapiens Q9H3F6
Anti Tag CoIP
33961781
Intra
TNFAIP1 Q13829 KCTD10 Homo sapiens Q9H3F6
Y2H Array
32296183
Intra
TNFAIP1 Q13829 GATM Homo sapiens P50440
Validated Y2H
32814053
Intra
TNFAIP1 Q13829 GATM Homo sapiens P50440
Y2H Pooling
32814053
Intra
TNFAIP1 Q13829 GATM Homo sapiens P50440
Y2H Array
32814053
Intra
TNFAIP1 Q13829 CDC37 Homo sapiens Q16543
Validated Y2H
32296183
Intra
TNFAIP1 Q13829 PSMA1 Homo sapiens P25786
Validated Y2H
25416956
Intra
TNFAIP1 Q13829 EXOSC5 Homo sapiens Q9NQT4
Validated Y2H
32296183
Intra
TNFAIP1 Q13829 NXF1 Homo sapiens Q9UBU9
Validated Y2H
32296183
Intra
TNFAIP1 Q13829 GRB2 Homo sapiens P62993
Y2H Array
32814053
Intra
TNFAIP1 Q13829 GRB2 Homo sapiens P62993
Y2H Pooling
32814053
Intra
TNFAIP1 Q13829 GRB2 Homo sapiens P62993
Validated Y2H
32814053
Intra
TNFAIP1 Q13829 HEXIM2 Homo sapiens Q96MH2
Validated Y2H
32296183
Intra
TNFAIP1 Q13829 RHOB Homo sapiens P62745
Anti Tag CoIP
19637314
Intra
TNFAIP1 Q13829 RHOB Homo sapiens P62745
Confocal
19637314
Intra
TNFAIP1 Q13829 SRC Homo sapiens P12931
Validated Y2H
32814053
Intra
TNFAIP1 Q13829 SRC Homo sapiens P12931
Y2H Array
32814053
Intra
TNFAIP1 Q13829 SRC Homo sapiens P12931
Y2H Pooling
32814053
Intra
TNFAIP1 Q13829 EPM2AIP1 Homo sapiens Q7L775
Y2H Array
25416956
Intra
TNFAIP1 Q13829 EPM2AIP1 Homo sapiens Q7L775
Validated Y2H
25416956
Intra
TNFAIP1 Q13829 EPM2AIP1 Homo sapiens Q7L775
Y2H Prey Pooling
25416956
Intra
TNFAIP1 Q13829 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
TNFAIP1 Q13829 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
TNFAIP1 Q13829 ARMC7 Homo sapiens Q9H6L4
Y2H Array
25416956
Intra
TNFAIP1 Q13829 ARMC7 Homo sapiens Q9H6L4
Y2H Prey Pooling
32296183
Intra
TNFAIP1 Q13829 ARMC7 Homo sapiens Q9H6L4
Y2H Prey Pooling
25416956
Intra
TNFAIP1 Q13829 ARMC7 Homo sapiens Q9H6L4
Validated Y2H
32296183
Intra
TNFAIP1 Q13829 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra
TNFAIP1 Q13829 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra
TNFAIP1 Q13829 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra
TNFAIP1 Q13829 ZMYND19 Homo sapiens Q96E35
Validated Y2H
32296183
Intra
TNFAIP1 Q13829 STK16 Homo sapiens O75716
Validated Y2H
25416956
Intra
TNFAIP1 Q13829 CARD9 Homo sapiens Q9H257
Y2H Prey Pooling
25416956
Intra
TNFAIP1 Q13829 CARD9 Homo sapiens Q9H257
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pontocerebellar Hypoplasia, Type 16

  • PCH16

  • Pontocerebellar Hypoplasia Type 16

  • Pontocerebellar Hypoplasia 16

  • Doid:0112333
Neurotic Excoriation

  • Factitious Skin Disease

  • Dermatitis Artefacta

  • Dermatitis Factitia

  • Dermatitis Ficta
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14787 TNFAIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TNFAIP1 MGD MGI:104961
Felis catus TNFAIP1 VGNC VGNC:66397
Rattus norvegicus TNFAIP1 RGD RGD:3877
Canis familiaris TNFAIP1 VGNC VGNC:47648
Bos taurus TNFAIP1 VGNC VGNC:36154
Macaca mulatta TNFAIP1 VGNC VGNC:78578
Others TNFAIP1 NCBI