KCTD13 - potassium channel tetramerization domain containing 13 Gene

Also Known as PDIP1; FKSG86; BACURD1; POLDIP1; hBACURD1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 253980

About KCTD13

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:29,906,339-29,926,226 (from NCBI)

This gene has 12 transcripts (splice variants), 218 orthologues and 2 paralogues. Broad expression in testis (RPKM 12.8), brain (RPKM 4.9) and 23 other tissues.

Summary

Enables identical protein binding activity and small GTPase binding activity. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including cellular protein metabolic process; negative regulation of Rho protein signal transduction; and stress fiber assembly. Located in nuclear body. Part of Cul3-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

KCTD13 Products (2)

mRNA	Protein	Name
NM_001410898.1	NP_001397827.1	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 isoform 2
NM_178863.5	NP_849194.1	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	19782033	GOA
contributes to ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	19782033	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell migration	IMP IMP: Inferred from mutant phenotype	19782033	GOA
involved in negative regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	19782033	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	19782033	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	19782033	GOA
involved in stress fiber assembly	IMP IMP: Inferred from mutant phenotype	19782033	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Cul3-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	19782033	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCTD13 Protein Structure

BTB_2

0
100
200
300
329 a.a.

Protein Preferred Names	Protein Names
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1	BTB/POZ domain-containing protein KCTD13

KCTD13 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KCTD13	Q8WZ19	MAT2A	Homo sapiens	P31153	Y2H Array	32814053
Intra	KCTD13	Q8WZ19	MAT2A	Homo sapiens	P31153	Validated Y2H	32814053
Intra	KCTD13	Q8WZ19	MAT2A	Homo sapiens	P31153	Y2H Pooling	32814053
Intra	KCTD13	Q8WZ19	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	KCTD13	Q8WZ19	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	KCTD13	Q8WZ19	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	KCTD13	Q8WZ19	TNFAIP1	Homo sapiens	Q13829	Anti Tag CoIP	33961781
Intra	KCTD13	Q8WZ19	TNFAIP1	Homo sapiens	Q13829	Anti Tag CoIP	28514442
Intra	KCTD13	Q8WZ19	TNFAIP1	Homo sapiens	Q13829	Y2H Prey Pooling	25416956
Intra	KCTD13	Q8WZ19	TNFAIP1	Homo sapiens	Q13829	Y2H Prey Pooling	32296183
Intra	KCTD13	Q8WZ19	TNFAIP1	Homo sapiens	Q13829	Y2H Array	25416956
Intra	KCTD13	Q8WZ19	TNFAIP1	Homo sapiens	Q13829	Anti Tag CoIP	19615732
Intra	KCTD13	Q8WZ19	TNFAIP1	Homo sapiens	Q13829	Y2H Array	32296183
Intra	KCTD13	Q8WZ19	KCTD10	Homo sapiens	Q9H3F6	Anti Tag CoIP	33961781
Intra	KCTD13	Q8WZ19	KCTD10	Homo sapiens	Q9H3F6	Validated Y2H	32296183
Intra	KCTD13	Q8WZ19	KCTD10	Homo sapiens	Q9H3F6	Anti Tag CoIP	19615732
Intra	KCTD13	Q8WZ19	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	KCTD13	Q8WZ19	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	KCTD13	Q8WZ19	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	KCTD13	Q8WZ19	EXOSC5	Homo sapiens	Q9NQT4	Validated Y2H	32296183
Intra	KCTD13	Q8WZ19	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	KCTD13	Q8WZ19	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	KCTD13	Q8WZ19	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	KCTD13	Q8WZ19	CUL3	Homo sapiens	Q13618	Validated Y2H	25416956
Intra	KCTD13	Q8WZ19	CUL3	Homo sapiens	Q13618	Y2H Array	25416956
Intra	KCTD13	Q8WZ19	CUL3	Homo sapiens	Q13618	Anti Tag CoIP	33961781
Intra	KCTD13	Q8WZ19	FXR1	Homo sapiens	P51114	Anti Tag CoIP	21653829
Intra	KCTD13	Q8WZ19	FXR1	Homo sapiens	P51114	Y2H Pooling	21653829
Intra	KCTD13	Q8WZ19	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	KCTD13	Q8WZ19	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	KCTD13	Q8WZ19	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	KCTD13	Q8WZ19	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	KCTD13	Q8WZ19	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
Intra	KCTD13	Q8WZ19	LNX1	Homo sapiens	Q8TBB1	Y2H Array	29892012
Intra	KCTD13	Q8WZ19	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	KCTD13	Q8WZ19	ARMC7	Homo sapiens	Q9H6L4	Validated Y2H	32296183
Intra	KCTD13	Q8WZ19	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	32296183
Intra	KCTD13	Q8WZ19	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	25416956
Intra	KCTD13	Q8WZ19	ZMYND19	Homo sapiens	Q96E35	Y2H Prey Pooling	25416956
Intra	KCTD13	Q8WZ19	BAG3	Homo sapiens	O95817	Validated Y2H	32814053
Intra	KCTD13	Q8WZ19	BAG3	Homo sapiens	O95817	Y2H Array	32814053
Intra	KCTD13	Q8WZ19	BAG3	Homo sapiens	O95817	Y2H Pooling	32814053
Intra	KCTD13	Q8WZ19	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	KCTD13	Q8WZ19	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	KCTD13	Q8WZ19	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	KCTD13	Q8WZ19	FLNA	Homo sapiens	P21333-2	Validated Y2H	32814053
Intra	KCTD13	Q8WZ19	FLNA	Homo sapiens	P21333-2	Y2H Array	32814053
Intra	KCTD13	Q8WZ19	FLNA	Homo sapiens	P21333-2	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Osteoarthritis	Osteoarthrosis Degenerative Joint Disease Hypertrophic Arthritis Arthropathy Degenerative Polyarthritis Degenerative Arthritis Osteoarthrosis And Allied Disorder Arthritis, Degenerative Oa Osteoarthritis Deformans Osteoarthrosis Deformans Kashin-Beck Disease
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Scalp-Ear-Nipple Syndrome	Finlay-Marks Syndrome Sen Syndrome SENS Scalp Ear Nipple Syndrome Hereditary Syndrome Of Lumpy Scalp, Odd Ears And Rudimentary Nipples Hereditary Syndrome Of Lumpy Scalp, Odd Ears, And Rudimentary Nipples Indian Childhood Cirrhosis
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Chromosome 22q11.2 Deletion Syndrome, Distal	22q11.2 Deletion Syndrome Autosomal Dominant Opitz G/Bbb Syndrome Catch22 Cayler Cardiofacial Syndrome Conotruncal Anomaly Face Syndrome Digeorge Syndrome Sedlackova Syndrome Shprintzen Syndrome Velocardiofacial Syndrome 22q11.2 Distal Deletion Syndrome Distal 22q11.2 Microdeletion Syndrome 22q11.2ds Vcfs Velo-Cardio-Facial Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Chromosome 22q11.2 Deletion Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Deletion 22q11.2 Syndrome 22q11ds Catch 22 Digeorge Sequence Microdeletion 22q11.2 Monosomy 22q11 Takao Syndrome Distal Del(22)(Q11.2) Distal Monosomy 22q11.2 Catch 22 Syndrome Chromosome Deletion Syndrome 22q11.2, Distal
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07190	KCTD13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KCTD13	RGD	RGD:735189
Mus musculus	KCTD13	MGD	MGI:1923739
Macaca mulatta	KCTD13	VGNC	VGNC:104735
Bos taurus	KCTD13	VGNC	VGNC:30503
Canis familiaris	KCTD13	VGNC	VGNC:42302
Felis catus	KCTD13	VGNC	VGNC:63054
Others	KCTD13	NCBI