RHOB - ras homolog family member B Gene

Also Known as ARH6; ARHB; RHOH6; MST081; MSTP081

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 388

About RHOB

Cytogenetic location: 2p24.1 Genomic coordinates (GRCh38): 2:20,447,074-20,449,440 (from NCBI)

This gene has 1 transcript (splice variant), 190 orthologues and 22 paralogues.

Summary

Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to ionizing radiation; and regulation of cell migration. Located in cleavage furrow and endosome membrane. Biomarker of breast Cancer. [provided by Alliance of Genome Resources, Apr 2022]

RHOB Products (1)

mRNA	Protein	Name
NM_004040.4	NP_004031.1	rho-related GTP-binding protein RhoB

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19637314	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	21373644	GOA
involved in cellular response to ionizing radiation	IDA IDA: Inferred from direct assay	21373644	GOA
involved in endosome to lysosome transport	IDA IDA: Inferred from direct assay	10508588	GOA
involved in endothelial tube morphogenesis	IMP IMP: Inferred from mutant phenotype	21347332	GOA
involved in mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	16236794	GOA
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	20460403	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	21373644	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	21347332	GOA
involved in regulation of cell migration	IGI IGI: Inferred from genetic interaction	20460403	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cleavage furrow	IDA IDA: Inferred from direct assay	16236794	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	15226397	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15226397	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHOB Protein Structure

Ras

0
100
196 a.a.

Protein Preferred Names	Protein Names
rho-related GTP-binding protein RhoB	Aplysia RAS-related homolog 6

RHOB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RHOB	P62745	TNFAIP1	Homo sapiens	Q13829	Y2H	19637314
Intra	RHOB	P62745	SMURF1	Homo sapiens	Q9HCE7-2	Pull Down	25249323

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Tangier Disease	Analphalipoproteinemia High Density Lipoprotein Deficiency, Tangier Type TGD High Density Lipoprotein Deficiency, Type 1 Hdldt1 Familial High Density Lipoprotein Deficiency A-Alphalipoprotein Neuropathy Alpha High Density Lipoprotein Deficiency Disease Cholesterol Thesaurismosis Familial High Density Lipoprotein Deficiency Disease Hdl Lipoprotein Deficiency Disease Tangier Disease Neuropathy Familial Alpha-Lipoprotein Deficiency Familial High-Density Lipoprotein Deficiency 1 Primary Hypoalphalipoproteinemia 1 Analphalipo-Proteinemia Familial Hypoalphalipo-Proteinemia Familial Hypoalphalipoproteinemia Lipoprotein Deficiency Disease, Hdl, Familial Tangier Hereditary Neuropathy Atp-Binding Cassette Transporter A1 Deficiency Hdld1 High Density Lipoprotein Deficiency 1 Tangier Disease, Variant Hypoalphalipoproteinemia, Familial Familial Hdl Deficiency
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11946	RHOB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-176902	NSC126188		/	Unkown
HY-28099	VEC6		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RHOB	VGNC	VGNC:45555
Bos taurus	RHOB	VGNC	VGNC:33944
Mus musculus	RHOB	MGD	MGI:107949
Felis catus	RHOB	VGNC	VGNC:68084
Rattus norvegicus	RHOB	RGD	RGD:621309
Others	RHOB	NCBI