NSC126188
NSC126188 is a RhoB inducer. NSC126188 can induce apoptosis by inhibiting Akt/FoxO3 signaling. NSC126188 can be used for the research of cancer, such as prostate cancer.
For research use only. We do not sell to patients.
- CAS No.: 31863-82-8
- Formula: C22H45IN2O
- Molecular Weight:480.51
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
RhoB |
FOXO3 |
NSC126188 (1-10 μM, 1-12 h) inhibits proliferation (GI50 = 0.7 μM) and induces apoptosis in human prostate cancer PC-3 cells[1].
NSC126188 (5 μM, 1 h) significantly reduces the phosphorylation levels of Akt at S473 and T308 sites in PC-3 cells
NSC126188 (5 μM, 30 mins) completely blocks insulin-induced translocation of Akt to the plasma membrane in PC-3 cells transfected with GFP-Akt;
NSC126188 (5 μM, 3-9 h) induces dephosphorylation of FoxO3a and upregulates RhoB expressionin PC-3 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:PC-3 cells
-
Concentration:1, 3, 5 and 10 μM
-
Incubation Time:1, 3, 6, 9 and 12 h
-
Result:Increased caspase-3, cleaved PARP, p21 and RhoB proteins.
Downregulated cyclin D1 levels.
Chemical Information
-
CAS No. 31863-82-8
-
Molecular Weight 480.51
-
Formula C22H45IN2O
-
SMILES
O=C(CCCCCCCCCCCCCCC)N1CC[N+](C)(CC1)C.[I-]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz