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Cat. No.: HY-176902

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NSC126188

NSC126188 is a RhoB inducer. NSC126188 can induce apoptosis by inhibiting Akt/FoxO3 signaling. NSC126188 can be used for the research of cancer, such as prostate cancer.

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CAS No.: 31863-82-8
Formule: C₂₂H₄₅IN₂O
Masse moléculaire:480.51

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

NSC126188 Chemical Structure

CAS No.: 31863-82-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

NSC126188 is a RhoB inducer. NSC126188 can induce apoptosis by inhibiting Akt/FoxO3 signaling. NSC126188 can be used for the research of cancer, such as prostate cancer^[1].

IC₅₀ & Target^[1]

RhoB

FOXO3

Voir tous les produits spécifiques à Isoform ROCK :

Voir tous les produits spécifiques à Isoform Akt :

Voir tous les produits spécifiques à Isoform FOXO :

FOXO1
FOXO3

In Vitro

NSC126188 (1-10 μM, 1-12 h) inhibits proliferation (GI₅₀ = 0.7 μM) and induces apoptosis in human prostate cancer PC-3 cells^[1].
NSC126188 (5 μM, 1 h) significantly reduces the phosphorylation levels of Akt at S473 and T308 sites in PC-3 cells NSC126188 (5 μM, 30 mins) completely blocks insulin-induced translocation of Akt to the plasma membrane in PC-3 cells transfected with GFP-Akt; NSC126188 (5 μM, 3-9 h) induces dephosphorylation of FoxO3a and upregulates RhoB expressionin PC-3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

PC-3 cells
Concentration:

1, 3, 5 and 10 μM
Incubation Time:

1, 3, 6, 9 and 12 h
Result:

Increased caspase-3, cleaved PARP, p21 and RhoB proteins.
Downregulated cyclin D1 levels.

Chemical Information

CAS No. 31863-82-8
Masse moléculaire 480.51
Formule C₂₂H₄₅IN₂O
SMILES

O=C(CCCCCCCCCCCCCCC)N1CC[N+](C)(CC1)C.[I-]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Won KJ, et al. NSC126188 induces apoptosis of prostate cancer PC-3 cells through inhibition of Akt membrane translocation, FoxO3a activation, and RhoB transcription. Apoptosis. 2014 Jan;19(1):179-90. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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NSC126188

Voir tous les produits spécifiques à Isoform ROCK

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