CAPN7 - calpain 7 Gene

Also Known as PALBH; CALPAIN7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23473

Summary

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The Calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine Protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with Protease activity. [provided by RefSeq, Jul 2008]
Ubiquitous expression in thyroid (RPKM 16.5), ovary (RPKM 11.2) and 25 other tissues.

CAPN7 Products (7)

mRNA Protein Name
NM_001376086.1 NP_001363015.1 calpain-7 isoform 2
NM_001376087.1 NP_001363016.1 calpain-7 isoform 3
NM_001376089.1 NP_001363018.1 calpain-7 isoform 4
NM_001376090.1 NP_001363019.1 calpain-7 isoform 5
NM_001376091.1 NP_001363020.1 calpain-7 isoform 6
NM_001376093.1 NP_001363022.1 calpain-7 isoform 7
NM_014296.3 NP_055111.1 calpain-7 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables MIT domain binding IPI
IPI: Inferred from physical interaction
20849418 GOA
enables endopeptidase activity IDA
IDA: Inferred from direct assay
20849418 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20849418 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of epithelial cell migration IDA
IDA: Inferred from direct assay
23855590 GOA
involved in self proteolysis IDA
IDA: Inferred from direct assay
20849418 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAPN7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CAPN7 Q9Y6W3 CTBP2 Homo sapiens P56545-3
Y2H Prey Pooling
32296183
Intra
CAPN7 Q9Y6W3 CTBP2 Homo sapiens P56545-3
Y2H Array
32296183
Intra
CAPN7 Q9Y6W3 PPP1R13B Homo sapiens Q96KQ4
Y2H Array
32296183
Intra
CAPN7 Q9Y6W3 PPP1R13B Homo sapiens Q96KQ4
Y2H Prey Pooling
32296183
Intra
CAPN7 Q9Y6W3 CEP63 Homo sapiens Q96MT8-3
Y2H Prey Pooling
32296183
Intra
CAPN7 Q9Y6W3 CEP63 Homo sapiens Q96MT8-3
Y2H Array
32296183
Intra
CAPN7 Q9Y6W3 TNFAIP1 Homo sapiens Q13829
Y2H Array
32296183
Intra
CAPN7 Q9Y6W3 TNFAIP1 Homo sapiens Q13829
Y2H Prey Pooling
32296183
Intra
CAPN7 Q9Y6W3 IFT88 Homo sapiens Q13099
Y2H Array
32296183
Intra
CAPN7 Q9Y6W3 IFT88 Homo sapiens Q13099
Y2H Prey Pooling
32296183
Intra
CAPN7 Q9Y6W3 AXIN2 Homo sapiens Q9Y2T1
Y2H Prey Pooling
32296183
Intra
CAPN7 Q9Y6W3 AXIN2 Homo sapiens Q9Y2T1
Y2H Array
32296183
Intra
CAPN7 Q9Y6W3 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
CAPN7 Q9Y6W3 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
CAPN7 Q9Y6W3 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
CAPN7 Q9Y6W3 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
CAPN7 Q9Y6W3 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra
CAPN7 Q9Y6W3 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra
CAPN7 Q9Y6W3 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
CAPN7 Q9Y6W3 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra
CAPN7 Q9Y6W3 PRPSAP1 Homo sapiens Q14558
Y2H Prey Pooling
32296183
Intra
CAPN7 Q9Y6W3 PRPSAP1 Homo sapiens Q14558
Y2H Array
32296183
Intra
CAPN7 Q9Y6W3 MAD1L1 Homo sapiens Q9Y6D9
Y2H Prey Pooling
32296183
Intra
CAPN7 Q9Y6W3 MAD1L1 Homo sapiens Q9Y6D9
Y2H Array
32296183
Intra
CAPN7 Q9Y6W3 ARNT2 Homo sapiens Q9HBZ2
Y2H Prey Pooling
32296183
Intra
CAPN7 Q9Y6W3 ARNT2 Homo sapiens Q9HBZ2
Y2H Array
32296183
Intra
CAPN7 Q9Y6W3 IST1 Homo sapiens P53990
Pull Down
20849418
Intra
CAPN7 Q9Y6W3 IST1 Homo sapiens P53990
IF
24953135
Intra
CAPN7 Q9Y6W3 IST1 Homo sapiens P53990
Anti Tag CoIP
20849418
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (26)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01890 CAPN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-158022 CTSL/CAPN1-IN-1 Inhibitor / Unkown
HY-161342 CTSL/CAPN1-IN-2 Inhibitor / Unkown
HY-P3911 CAP 37 (20-44) / Unkown
HY-RS01883 CAPN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01884 CAPN10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01885 CAPN11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01886 CAPN12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01887 CAPN14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01888 CAPN15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01889 CAPN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01891 CAPN5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01892 CAPN6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01893 CAPN8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01894 CAPN9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01895 CAPNS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01896 CAPNS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17903 Capn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18379 Capn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20869 Capn5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22412 Capn8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22413 Capn9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24372 Capn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24859 Capn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27386 Capn5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28936 Capn8 Rat Pre-designed siRNA Set A / Unkown