1. GPCR/G Protein
  2. Adrenergic Receptor

Lofexidine 

Cat. No.: HY-B1052A Purity: 99.08%
Handling Instructions

Lofexidine is a selective α2-receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal.

For research use only. We do not sell to patients.

Lofexidine Chemical Structure

Lofexidine Chemical Structure

CAS No. : 31036-80-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
50 mg USD 100 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of Lofexidine:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Lofexidine is a selective α2-receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal[1][2].

IC50 & Target

α2-receptor[1][2].

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (241.19 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8591 mL 19.2953 mL 38.5907 mL
5 mM 0.7718 mL 3.8591 mL 7.7181 mL
10 mM 0.3859 mL 1.9295 mL 3.8591 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (8.03 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (8.03 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (8.03 mM); Clear solution

References
Molecular Weight

259.13

Formula

C₁₁H₁₂Cl₂N₂O

CAS No.

31036-80-3

SMILES

CC(C1=NCCN1)OC2=C(Cl)C=CC=C2Cl

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Lofexidine
Cat. No.:
HY-B1052A
Quantity:

Lofexidine

Cat. No.: HY-B1052A