31036-80-3
Chemical Structure
Lofexidine
Synonym(s): Baq-168 free base; MDL-14042 free base
- CAS No.: 31036-80-3
- Formula:C11H12Cl2N2O
- Molecular Weight:259.13
IUPAC Name: 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-1H-imidazole
InChIKey: KSMAGQUYOIHWFS-UHFFFAOYSA-N
SMILES: CC(C1=NCCN1)OC2=C(Cl)C=CC=C2Cl
Biological Activity: Lofexidine (Baq-168 free base) is an orally active agonist of the imidazoline I1 receptor (imidazoline I1 receptor) (Ki: 1.9 nM) and α2-adrenergic receptor (α2-adrenergic receptor). Lofexidine binds to the α2A-adrenergic receptor, reduces sympathetic outflow, lowers blood pressure, and exhibits vasoconstrictive effects. Lofexidine regulates the expression of c-fos and alleviates opioid withdrawal symptoms. Lofexidine is applicable to research on opioid addiction and withdrawal[1][2].
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Lofexidine | 99.08% | Lofexidine (Baq-168 free base) is an orally active agonist of the imidazoline I1 receptor (imidazoline I1 receptor) (Ki: 1.9 nM) and α2-adrenergic receptor (α2-adrenergic receptor). Lofexidine binds to the α2A-adrenergic receptor, reduces sympathetic outflow, lowers blood pressure, and exhibits vasoconstrictive effects. Lofexidine regulates the expression of c-fos and alleviates opioid withdrawal symptoms. Lofexidine is applicable to research on opioid addiction and withdrawal. | ||||||||||||||||||||
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- [1]. Vartak AP, et al. The preclinical discovery of lofexidine for the treatment of opiate addiction. Expert Opin Drug Discov. 2014;9(11):1371-1377. [Content Brief]
- [2]. Gish E C, et al. Lofexidine, an α2-receptor agonist for opioid detoxification[J]. Annals of Pharmacotherapy, 2010, 44(2): 343-351.
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