31036-80-3

Lofexidine Chemical Structure
31036-80-3

Chemical Structure

Lofexidine

Synonym(s): Baq-168 free base; MDL-14042 free base

  • CAS No.: 31036-80-3
  • Formula:C11H12Cl2N2O
  • Molecular Weight:259.13

IUPAC Name: 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-1H-imidazole

InChIKey: KSMAGQUYOIHWFS-UHFFFAOYSA-N

SMILES: CC(C1=NCCN1)OC2=C(Cl)C=CC=C2Cl

Biological Activity: Lofexidine (Baq-168 free base) is an orally active agonist of the imidazoline I1 receptor (imidazoline I1 receptor) (Ki: 1.9 nM) and α2-adrenergic receptor (α2-adrenergic receptor). Lofexidine binds to the α2A-adrenergic receptor, reduces sympathetic outflow, lowers blood pressure, and exhibits vasoconstrictive effects. Lofexidine regulates the expression of c-fos and alleviates opioid withdrawal symptoms. Lofexidine is applicable to research on opioid addiction and withdrawal[1][2].

Cat. No. Product Name Purity Description Pricing
HY-B1052A 		Lofexidine 99.08% Lofexidine (Baq-168 free base) is an orally active agonist of the imidazoline I1 receptor (imidazoline I1 receptor) (Ki: 1.9 nM) and α2-adrenergic receptor (α2-adrenergic receptor). Lofexidine binds to the α2A-adrenergic receptor, reduces sympathetic outflow, lowers blood pressure, and exhibits vasoconstrictive effects. Lofexidine regulates the expression of c-fos and alleviates opioid withdrawal symptoms. Lofexidine is applicable to research on opioid addiction and withdrawal.
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This product is a controlled substance and not for sale in your territory.

This product is not for sale in your territory.

This compound is listed in the SVHC (Substances of Very High Concern) candidate list of ECHA (European Chemicals Agency).

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Structural Analogs

References

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