A-582941 dihydrochloride

Cat. No.: HY-59201A Purity: 99.78%: Data Sheet
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A-582941 dihydrochloride is a selective, orally active, blood-brain barrier-permeable α7 nAChR agonist, with K_i values of 10.8 nM and 17 nM in rat brain and human frontal cortex, respectively. A-582941 dihydrochloride exhibits agonistic activity at 5-HT3 receptors, with a K_i of 150 nM. A-582941 dihydrochloride triggers phosphorylation of ERK1/2 and CREB, inhibits GSK-3β via Ser-9 phosphorylation, increases acetylcholine release, induces the expression of Arc and c-Fos, activates brain regions associated with working memory and attention, and reduces cell death caused by nerve growth factor (NGF) deprivation. A-582941 dihydrochloride is applicable for the research of Alzheimer's disease and schizophrenia.

For research use only. We do not sell to patients.

A-582941 dihydrochloride Chemical Structure

CAS No. : 848591-90-2

Size	Stock	Quantity

Free Sample (0.1 - 0.2 mg)	Apply Now
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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of A-582941 dihydrochloride:

A-582941 Get quote

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5-HT Receptor 5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor

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ERK ERK1 ERK2 ERK5 ERK8

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

α7 nAChR

10.8 nM (Ki, for rat α7 receptors)

α7 nAChR

16.7 nM (Ki, for human α7 receptors)

5-HT₃ Receptor

150 nM (Ki)

Molecular Weight

353.29

Formula

C₁₇H₂₂Cl₂N₄

CAS No.

848591-90-2

Appearance

Solid

Color

Light yellow to yellow

SMILES

CN1CC(CN(C2=NN=C(C3=CC=CC=C3)C=C2)C4)C4C1.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (283.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8305 mL	14.1527 mL	28.3054 mL
5 mM	0.5661 mL	2.8305 mL	5.6611 mL
10 mM	0.2831 mL	1.4153 mL	2.8305 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Purity & Documentation

Purity: 99.78%

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Data Sheet (272 KB) SDS (251 KB)

COA (246 KB) HNMR (259 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Tietje KR, et al. Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties. CNS Neurosci Ther. 2008;14(1):65-82. [Content Brief]

[2]. Thomsen MS, et al. The selective alpha7 nicotinic acetylcholine receptor agonist A-582941 activates immediate early genes in limbic regions of the forebrain: Differential effects in the juvenile and adult rat. Neuroscience. 2008;154(2):741-753. [Content Brief]

[3]. Buccafusco JJ, et al. Profile of nicotinic acetylcholine receptor agonists ABT-594 and A-582941, with differential subtype selectivity, on delayed matching accuracy by young monkeys. Biochem Pharmacol. 2007;74(8):1202-1211. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8305 mL	14.1527 mL	28.3054 mL	70.7634 mL
	5 mM	0.5661 mL	2.8305 mL	5.6611 mL	14.1527 mL
	10 mM	0.2831 mL	1.4153 mL	2.8305 mL	7.0763 mL
	15 mM	0.1887 mL	0.9435 mL	1.8870 mL	4.7176 mL
	20 mM	0.1415 mL	0.7076 mL	1.4153 mL	3.5382 mL
	25 mM	0.1132 mL	0.5661 mL	1.1322 mL	2.8305 mL
	30 mM	0.0944 mL	0.4718 mL	0.9435 mL	2.3588 mL
	40 mM	0.0708 mL	0.3538 mL	0.7076 mL	1.7691 mL
	50 mM	0.0566 mL	0.2831 mL	0.5661 mL	1.4153 mL
	60 mM	0.0472 mL	0.2359 mL	0.4718 mL	1.1794 mL
	80 mM	0.0354 mL	0.1769 mL	0.3538 mL	0.8845 mL
	100 mM	0.0283 mL	0.1415 mL	0.2831 mL	0.7076 mL