KTT-1
KTT-1 is a kinetically selective and orally active HDAC2 inhibitor. KTT-1 exhibits high HDAC2-selectivity over HDAC1. KTT-1 inhibits osteoclast differentiation at an early stage by downregulating c-Fos expression. KTT-1 effectively suppresses arthritis symptoms in the collagen-induced arthritis (CIA) mouse model. KTT-1 can be used for the research of rheumatoid arthritis and neurodegenerative diseases.
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- CAS No.: 2397562-26-2
- Formule: C26H21N5O4S
- Masse moléculaire:499.54
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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HDAC2 |
KTT-1 (25-200 nM; Bone Marrow-Derived Macrophages (BM cells)) reduces the number of osteoclasts and the expression of key osteoclast differentiation genes[1].
KTT-1 (25-100 nM; Bone Marrow-Derived Macrophages (BMDMs)) reduces IL-1β and IL-6 production without affecting TNF-α production[1].
KTT-1 (Day 6, Day 8, Day 10; Bone Marrow-Derived Macrophages (BM cells)) alters gene expression and arrests osteoclast differentiation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
KTT-1 (0.03 mg/mL (6 mg/kg/day); drinking water; 22 days) alleviates arthritis severity in CAIA model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DBA/1JJmsSlc (male, 6-7 weeks old, collagen-induced arthritis (CIA) model)[1]
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Dosage:0.03 mg/mL (6 mg/kg/day)
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Administration:Drinking water; 10 consecutive days
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Result:Arthritis severity was significantly attenuated, as evidenced by reduced clinical scores and histological scores.
Showed markedly reduced synovial inflammation and immune cell infiltration, with preservation of normal joint architecture.
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Animal Model:DBA/1JJmsSlc (male, 6-7 weeks old, collagen antibody-induced arthritis (CAIA) model)[1]
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Dosage:0.03 mg/mL (6 mg/kg/day)
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Administration:Drinking water; 22 days
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Result:Arthritis severity was significantly alleviated, as indicated by reduced clinical scores and improved body weight gain.
Chemical Information
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CAS No. 2397562-26-2
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Masse moléculaire 499.54
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Formule C26H21N5O4S
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SMILES
O=C(NC1=CC(C2=CC=CO2)=CC=C1N)C(C=C3)=CC=C3C(N=N4)=CN4CS(=O)(C5=CC=CC=C5)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KTT-1 Related Classifications
HY-179216 Related Classifications
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