2397562-26-2
Chemical Structure
KTT-1
- CAS No.: 2397562-26-2
- Formula:C26H21N5O4S
- Molecular Weight:499.54
InChIKey: XCJIKXQBHOGKHC-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(C2=CC=CO2)=CC=C1N)C(C=C3)=CC=C3C(N=N4)=CN4CS(=O)(C5=CC=CC=C5)=O
Biological Activity: KTT-1 is a kinetically selective and orally active HDAC2 inhibitor. KTT-1 exhibits high HDAC2-selectivity over HDAC1. KTT-1 inhibits osteoclast differentiation at an early stage by downregulating c-Fos expression. KTT-1 effectively suppresses arthritis symptoms in the collagen-induced arthritis (CIA) mouse model. KTT-1 can be used for the research of rheumatoid arthritis and neurodegenerative diseases[1][2].
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KTT-1 | KTT-1 is a kinetically selective and orally active HDAC2 inhibitor. KTT-1 exhibits high HDAC2-selectivity over HDAC1. KTT-1 inhibits osteoclast differentiation at an early stage by downregulating c-Fos expression. KTT-1 effectively suppresses arthritis symptoms in the collagen-induced arthritis (CIA) mouse model. KTT-1 can be used for the research of rheumatoid arthritis and neurodegenerative diseases. | |||||||||||||||||||||
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- [1]. Yumi Ogihara, et al. The HDAC2-selective inhibitor KTT-1 attenuates autoimmune arthritis by inhibiting osteoclast differentiation in mice. bioRxiv. October 21, 2025.
- [2]. Mishima H, et al. Origin of the kinetic HDAC2-selectivity of an HDAC inhibitor. J Comput Chem. 2023;44(18):1604-1609. [Content Brief]
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