Cannabidiolic acid methyl ester
Cannabidiolic acid methyl ester (HU-580) is an orally active cannabidiolic acid analogue. Cannabidiolic acid methyl ester can enhance the activation of 5-HT1A receptor and increase the expression of c-Fos and NeuN in specific hypothalamic nuclei of rats. Cannabidiolic acid methyl ester has anti-nausea, anti-anxiety and anti-injury effects.
For research use only. We do not sell to patients.
- CAS No.: 55658-71-4
- Formula: C23H32O4
- Molecular Weight:372.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
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5-HT1A Receptor |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero C1008 | CC50 |
52.4 μM
Compound: 8
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Cytotoxicity against African green monkey Vero E6 cells measured after 72 hrs by LDH assay
Cytotoxicity against African green monkey Vero E6 cells measured after 72 hrs by LDH assay
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[PMID: 37402317] |
Chemical Information
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CAS No. 55658-71-4
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Molecular Weight 372.50
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Formula C23H32O4
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SMILES
CC([C@H]1[C@H](C2=C(C(C(OC)=O)=C(C=C2O)CCCCC)O)C=C(CC1)C)=C
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Synonyms
HU-580
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Pertwee RG, et al. Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5-HT1A receptor-mediated suppression of nausea and anxiety in rats. Br J Pharmacol. 2018 Jan;175(1):100-112. [Content Brief]
[2]. Zhu YF, et al. An evaluation of the anti-hyperalgesic effects of cannabidiolic acid-methyl ester in a preclinical model of peripheral neuropathic pain. Br J Pharmacol. 2020 Jun;177(12):2712-2725. [Content Brief]
[3]. Murillo-Rodríguez E, et al.Assessing the treatment of cannabidiolic acid methyl ester: a stable synthetic analogue of cannabidiolic acid on c-Fos and NeuN expression in the hypothalamus of rats. J Cannabis Res. 2021 Jul 12;3(1):31. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cannabidiolic acid methyl ester Related Classifications
HY-169451 Related Classifications
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