55658-71-4
55658-71-4
Chemical Structure
Cannabidiolic acid methyl ester
Synonym(s): HU-580
- CAS No.: 55658-71-4
- Formula:C23H32O4
- Molecular Weight:372.50
InChIKey: GSBCCWIIKCFQKI-ZWKOTPCHSA-N
SMILES: CC([C@H]1[C@H](C2=C(C(C(OC)=O)=C(C=C2O)CCCCC)O)C=C(CC1)C)=C
Biological Activity: Cannabidiolic acid methyl ester (HU-580) is an orally active cannabidiolic acid analogue. Cannabidiolic acid methyl ester can enhance the activation of 5-HT1A receptor and increase the expression of c-Fos and NeuN in specific hypothalamic nuclei of rats. Cannabidiolic acid methyl ester has anti-nausea, anti-anxiety and anti-injury effects[1][2][3].
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Cannabidiolic acid methyl ester | Cannabidiolic acid methyl ester (HU-580) is an orally active cannabidiolic acid analogue. Cannabidiolic acid methyl ester can enhance the activation of 5-HT1A receptor and increase the expression of c-Fos and NeuN in specific hypothalamic nuclei of rats. Cannabidiolic acid methyl ester has anti-nausea, anti-anxiety and anti-injury effects. | |||||||||||||||||||||
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References
- [1]. Pertwee RG, et al. Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5-HT1A receptor-mediated suppression of nausea and anxiety in rats. Br J Pharmacol. 2018 Jan;175(1):100-112. [Content Brief]
- [2]. Zhu YF, et al. An evaluation of the anti-hyperalgesic effects of cannabidiolic acid-methyl ester in a preclinical model of peripheral neuropathic pain. Br J Pharmacol. 2020 Jun;177(12):2712-2725. [Content Brief]
- [3]. Murillo-Rodríguez E, et al.Assessing the treatment of cannabidiolic acid methyl ester: a stable synthetic analogue of cannabidiolic acid on c-Fos and NeuN expression in the hypothalamus of rats. J Cannabis Res. 2021 Jul 12;3(1):31. [Content Brief]
Keywords
