Osemozotan hydrochloride
Osemozotan hydrochloride (MKC242) is a selective 5-HT1A receptor agonist. Osemozotan hydrochloride decreases the number of c-Fos-positive cells caused by MAMP in mice. Osemozotan hydrochloride can be used for the research of depressive disorder.
For research use only. We do not sell to patients.
- CAS No.: 137275-80-0
- Formula: C19H22ClNO5
- Molecular Weight:379.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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5-HT1A Receptor |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female CD-1 mice with picrotoxin-induced decrease in female preference[1]
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Dosage:1 mg/kg
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Administration:Intraperitoneal injection; 1 mg/kg; 20 min after picrotoxin treatment
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Result:Ameliorated the picrotoxin-induced decrease in the female preference by co-administration WITH (+)-SKF-10,047 (5 mg/kg). Showed no effect on the picrotoxin-induced decrease in the female preference when treated alone.
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Animal Model:ICR mice with MAMP injection[2]
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Dosage:1 mg/kg
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Administration:Intraperitoneal injection; 1 mg/kg; once
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Result:Significantly decreased the number of c-Fos-positive cells induced by MAMP in the medial prefrontal cortex and striatum, but did not change the number of c-Fos-positive cells.
Chemical Information
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CAS No. 137275-80-0
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Molecular Weight 379.83
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Formula C19H22ClNO5
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SMILES
[H]Cl.[C@@H]1(CNCCCOC2=CC=C(OCO3)C3=C2)OC4=CC=CC=C4OC1
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Synonyms
MKC242
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hasebe S, et al. Anti-anhedonic effect of selective serotonin reuptake inhibitors with affinity for sigma-1 receptors in picrotoxin-treated mice. Br J Pharmacol. 2017 Feb;174(4):314-327. [Content Brief]
[2]. Tsuchida R, et al. Inhibitory effects of osemozotan, a serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos expression in prefrontal cortical neurons. Biol Pharm Bull. 2009 Apr;32(4):728-31. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Osemozotan hydrochloride Related Classifications
HY-100426A Related Classifications
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