2. Osemozotan hydrochloride

Osemozotan hydrochloride  (Synonyms: MKC242)

Cat. No.: HY-100426A
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Osemozotan hydrochloride (MKC242) is a selective 5-HT1A receptor agonist. Osemozotan hydrochloride decreases the number of c-Fos-positive cells caused by MAMP in mice. Osemozotan hydrochloride can be used for the research of depressive disorder.

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Osemozotan hydrochloride Chemical Structure

Osemozotan hydrochloride Chemical Structure

CAS No. : 137275-80-0

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Description

Osemozotan hydrochloride (MKC242) is a selective 5-HT1A receptor agonist. Osemozotan hydrochloride decreases the number of c-Fos-positive cells caused by MAMP in mice. Osemozotan hydrochloride can be used for the research of depressive disorder[1][2].

In Vivo

Osemozotan hydrochloride (1 mg/kg; i.p.; 20 min after picrotoxin treatment) ameliorates picrotoxin-induced decrease in female preference with the combination of (+)-SKF-10,047[1].
Osemozotan hydrochloride (1 mg/kg; i.p.; once) decreases the number of c-Fos-positive cells caused by MAMP[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CD-1 mice with picrotoxin-induced decrease in female preference[1]
Dosage: 1 mg/kg
Administration: Intraperitoneal injection; 1 mg/kg; 20 min after picrotoxin treatment
Result: Ameliorated the picrotoxin-induced decrease in the female preference by co-administration WITH (+)-SKF-10,047 (5 mg/kg). Showed no effect on the picrotoxin-induced decrease in the female preference when treated alone.
Animal Model: ICR mice with MAMP injection[2]
Dosage: 1 mg/kg
Administration: Intraperitoneal injection; 1 mg/kg; once
Result: Significantly decreased the number of c-Fos-positive cells induced by MAMP in the medial prefrontal cortex and striatum, but did not change the number of c-Fos-positive cells.
Molecular Weight

379.83

Formula

C19H22ClNO5
CAS No.
SMILES

[H]Cl.[C@@H]1(CNCCCOC2=CC=C(OCO3)C3=C2)OC4=CC=CC=C4OC1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Osemozotan137275-80-0MKC242MKC 242MKC-242Inhibitorinhibitorinhibit

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