137275-80-0
Chemical Structure
Osemozotan hydrochloride
Synonym(s): MKC242
- CAS No.: 137275-80-0
- Formula:C19H22ClNO5
- Molecular Weight:379.83
IUPAC Name: (S)-3-(benzo[d][1,3]dioxol-5-yloxy)-N-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)propan-1-amine hydrochloride
InChIKey: GGNCUSDIUUCNKE-RSAXXLAASA-N
SMILES: [H]Cl.[C@@H]1(CNCCCOC2=CC=C(OCO3)C3=C2)OC4=CC=CC=C4OC1
Biological Activity: Osemozotan hydrochloride (MKC242) is a selective 5-HT1A receptor agonist. Osemozotan hydrochloride decreases the number of c-Fos-positive cells caused by MAMP in mice. Osemozotan hydrochloride can be used for the research of depressive disorder[1][2].
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Osemozotan hydrochloride | Osemozotan hydrochloride (MKC242) is a selective 5-HT1A receptor agonist. Osemozotan hydrochloride decreases the number of c-Fos-positive cells caused by MAMP in mice. Osemozotan hydrochloride can be used for the research of depressive disorder. | |||||||||||||||||||||
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- [1]. Hasebe S, et al. Anti-anhedonic effect of selective serotonin reuptake inhibitors with affinity for sigma-1 receptors in picrotoxin-treated mice. Br J Pharmacol. 2017 Feb;174(4):314-327. [Content Brief]
- [2]. Tsuchida R, et al. Inhibitory effects of osemozotan, a serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos expression in prefrontal cortical neurons. Biol Pharm Bull. 2009 Apr;32(4):728-31. [Content Brief]
Keywords
