2. GPCR/G Protein Neuronal Signaling Stem Cell/Wnt MAPK/ERK Pathway Epigenetics
  3. CGRP Receptor 5-HT Receptor ERK Epigenetic Reader Domain
  4. PCC0105005

PCC0105005 is a dual-target CGRP Receptor antagonist (IC50 = 1.01 nM) and a partial agonist of 5-HT1F Receptor (EC50 = 77.91 nM). PCC0105005 shows significant efficacy in the rat model of migraine. PCC0105005 significantly reduces the expression of CGRP and c-Fos proteins, and inhibits the phosphorylation levels of ERK and CREB. PCC0105005 can be used for research on migraine.

For research use only. We do not sell to patients.

PCC0105005

PCC0105005 Chemical Structure

CAS No. : 2921670-99-5

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PCC0105005 Related Antibodies

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Description

PCC0105005 is a dual-target CGRP Receptor antagonist (IC50 = 1.01 nM) and a partial agonist of 5-HT1F Receptor (EC50 = 77.91 nM). PCC0105005 shows significant efficacy in the rat model of migraine. PCC0105005 significantly reduces the expression of CGRP and c-Fos proteins, and inhibits the phosphorylation levels of ERK and CREB. PCC0105005 can be used for research on migraine[1].

IC50 & Target[1]

5-HT1F Receptor

77.91 nM (IC50)

ERK

 

Molecular Weight

894.12

Formula

C51H63N11O4
CAS No.
SMILES

CN(CC1)CCC1C2=CNC3=CC=C(NC(C4=CC(C=C(C5CCN(C(N[C@H](CC6=CC(C)=C(NN=C7)C7=C6)C(N8CCN(C9CCN(C)CC9)CC8)=O)=O)CC5)C(N%10)=O)=C%10C=C4)=O)C=C32
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Purity & Documentation
References
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PCC0105005 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PCC01050052921670-99-5PCC 0105005PCC-0105005CGRP Receptor5-HT ReceptorERKEpigenetic Reader DomainCalcitonin gene-related peptide receptor Serotonin Receptor5-hydroxytryptamine ReceptorExtracellular signal regulated kinasesDual-target therapeuticsCGRP antagonists5-HT1F agonistsmigraine treatmentstructure-based drug designpharmacokineticsperipheral restrictiontrigeminovascular systemneurogenic inflammationpain thresholdInhibitorinhibitorinhibit

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