12(S)-HPETE
12(S)-HPETE is a 12-hydroxyeicosatetraenoic acid. 12(S)-HPETE has the function of regulating vascular tone. 12(S)-HPETE induces the expression of c-Fos and c-Jun protein and increases activating protein 1 (AP-1) activity in vascular smooth muscle cells.12(S)-HPETE may play a physiological role in vasomotor regulation through endothelium itself and crosstalk between blood cells and endothelium. 12(S)-HPETE can be used in the study of cerebrovascular tension.
For research use only. We do not sell to patients.
- CAS No.: 71774-10-2
- Formula: C20H32O4
- Molecular Weight:336.47
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All AP-1 Isoforms
More
Biological Activity
Chemical Information
-
CAS No. 71774-10-2
-
Molecular Weight 336.47
-
Formula C20H32O4
-
SMILES
CCCCC/C=C\C[C@H](OO)/C=C/C=C\C/C=C\CCCC(O)=O
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
-
Data Sheet (261 KB)
-
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Nishiyama M, et al. Endothelium is required for 12-hydroperoxyeicosatetraenoic acid-induced vasoconstriction. Eur J Pharmacol. 1998 Jan 2;341(1):57-63. [Content Brief]
[2]. Rao GN, et al. Role of hydroperoxyeicosatetraenoic acids in oxidative stress-induced activating protein 1 (AP-1) activity. J Biol Chem. 1996 Nov 1;271(44):27760-4. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)