71774-10-2
Chemical Structure
12(S)-HPETE
- CAS No.: 71774-10-2
- Formula:C20H32O4
- Molecular Weight:336.47
IUPAC Name: (S,5Z,8Z,10E,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoic acid
InChIKey: ZIOZYRSDNLNNNJ-LQWMCKPYSA-N
SMILES: CCCCC/C=C\C[C@H](OO)/C=C/C=C\C/C=C\CCCC(O)=O
Biological Activity: 12(S)-HPETE is a 12-hydroxyeicosatetraenoic acid. 12(S)-HPETE has the function of regulating vascular tone. 12(S)-HPETE induces the expression of c-Fos and c-Jun protein and increases activating protein 1 (AP-1) activity in vascular smooth muscle cells.12(S)-HPETE may play a physiological role in vasomotor regulation through endothelium itself and crosstalk between blood cells and endothelium. 12(S)-HPETE can be used in the study of cerebrovascular tension[1][2].
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12(S)-HPETE | 12(S)-HPETE is a 12-hydroxyeicosatetraenoic acid. 12(S)-HPETE has the function of regulating vascular tone. 12(S)-HPETE induces the expression of c-Fos and c-Jun protein and increases activating protein 1 (AP-1) activity in vascular smooth muscle cells.12(S)-HPETE may play a physiological role in vasomotor regulation through endothelium itself and crosstalk between blood cells and endothelium. 12(S)-HPETE can be used in the study of cerebrovascular tension. | |||||||||||||||||||||
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References
- [1]. Nishiyama M, et al. Endothelium is required for 12-hydroperoxyeicosatetraenoic acid-induced vasoconstriction. Eur J Pharmacol. 1998 Jan 2;341(1):57-63. [Content Brief]
- [2]. Rao GN, et al. Role of hydroperoxyeicosatetraenoic acids in oxidative stress-induced activating protein 1 (AP-1) activity. J Biol Chem. 1996 Nov 1;271(44):27760-4. [Content Brief]
