2. Gene
  3. GPR151 - G protein-coupled receptor 151 Gene

GPR151 - G protein-coupled receptor 151 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GPCR; PGR7; GALR4; GALRL; GPCR-2037

Gene ID: 134391 | Gene type: protein coding

About GPR151

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:146,513,144-146,516,190 (from NCBI)

This gene has 1 transcript (splice variant), 176 orthologues and 7 paralogues.

Summary

This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the SOG subfamily that includes somatostatin, opioid, Galanin, and kisspeptin receptors. The orthologous mouse gene has a restricted pattern of neuronal expression which is induced following nerve injury. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]

GPR151 Products(1)

mRNA Protein Name
NM_194251.3 NP_919227.2 G-protein coupled receptor 151

GPR151 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (53 - 306)

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  • 419 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor 151

G-protein coupled receptor PGR7

Related Diseases

Diseases Alias
Essential Tremor

Benign Essential Tremor

Familial Tremor

Hereditary Essential Tremor

Essential Hereditary Tremor

Shaky Hand Syndrome

Benign Essential Tremor Syndrome

Tremor Hereditary Essential

Essential Tremor, Susceptibility To

Tremor, Hereditary Essential
Tremor, Hereditary Essential, 4

ETM4

Essential Tremor 4

Essential Tremor, Hereditary, 4

Hereditary Essential Tremor 4

Tremor, Hereditary Essential 4

Tremor, Hereditary Essential, Type 4
Brachial Plexus Lesion

Brachial Plexus Injuries

Brachial Plexus Lesions
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05670 GPR151 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GPR151 VGNC VGNC:29558
Canis familiaris GPR151 VGNC VGNC:41405
Mus musculus GPR151 MGD MGI:2441887
Rattus norvegicus GPR151 RGD RGD:727873
Felis catus GPR151 VGNC VGNC:62679
Macaca mulatta GPR151 VGNC VGNC:72987