GZMK - granzyme K Gene

Homo sapiens

Also known as TRYP2

Gene ID: 3003 | Gene type: protein coding

About GZMK

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:55,024,256-55,034,570 (from NCBI)

This gene has 2 transcripts (splice variants), 116 orthologues and 5 paralogues. Biased expression in lymph node (RPKM 65.9), spleen (RPKM 22.6) and 7 other tissues.

Summary

This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually Peptides or proteins resulting from Infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008]

GZMK Products(1)

mRNA	Protein	Name
NM_002104.3	NP_002095.1	granzyme K precursor

GZMK Protein Structure

Trypsin

0
100
200
264 a.a.

Protein Preferred Names

Protein Names

granzyme K

NK-Tryp-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05942	GZMK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GZMK	VGNC	VGNC:67528
Rattus norvegicus	GZMK	RGD	RGD:68401
Canis familiaris	GZMK	VGNC	VGNC:41578
Bos taurus	GZMK	VGNC	VGNC:29733
Macaca mulatta	GZMK	VGNC	VGNC:73339
Mus musculus	GZMK	MGD	MGI:1298232
Others	GZMK	NCBI

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