LPAR6 - lysophosphatidic acid receptor 6 Gene

Homo sapiens

Also known as LAH3; P2Y5; ARWH1; HYPT8; LPA-6; P2RY5

Gene ID: 10161 | Gene type: protein coding

About LPAR6

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:48,389,571-48,444,669 (from NCBI)

This gene has 9 transcripts (splice variants), 244 orthologues, 16 paralogues and is associated with 3 phenotypes. Ubiquitous expression in placenta (RPKM 27.8), fat (RPKM 19.3) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

LPAR6 Products(11)

mRNA	Protein	Name
XM_047430022.1	XP_047285978.1	lysophosphatidic acid receptor 6 isoform X1
XM_047430024.1	XP_047285980.1	lysophosphatidic acid receptor 6 isoform X3
XM_047430023.1	XP_047285979.1	lysophosphatidic acid receptor 6 isoform X2
XM_047430020.1	XP_047285976.1	lysophosphatidic acid receptor 6 isoform X1
NM_001162498.3	NP_001155970.1	lysophosphatidic acid receptor 6
XM_047430021.1	XP_047285977.1	lysophosphatidic acid receptor 6 isoform X1
NM_001377316.2	NP_001364245.1	lysophosphatidic acid receptor 6
NM_001377317.2	NP_001364246.1	lysophosphatidic acid receptor 6
NM_005767.7	NP_005758.2	lysophosphatidic acid receptor 6
XM_047430019.1	XP_047285975.1	lysophosphatidic acid receptor 6 isoform X1
NM_001162497.3	NP_001155969.1	lysophosphatidic acid receptor 6

LPAR6 Protein Structure

7tm_1

0
100
200
300
344 a.a.

Protein Preferred Names

Protein Names

lysophosphatidic acid receptor 6

G-protein coupled purinergic receptor P2Y5	LPA receptor 6
P2Y purinoceptor 5	RB intron encoded G-protein coupled receptor
oleoyl-L-alpha-lysophosphatidic acid receptor	purinergic receptor 5
purinergic receptor P2Y G protein-coupled protein 5	purinergic receptor P2Y, G-protein coupled, 5

Related Diseases

Diseases

Alias

Leukocoria

Leucocoria

Hypotrichosis 8

HYPT8	Lah3
Hypotrichosis, Localized, Autosomal Recessive 3	Woolly Hair, Autosomal Recessive 1, With Or Without Hypotrichosis
Autosomal Recessive Woolly Hair 1, With Or Without Hypotrichosis	Hypotrichosis Localized Autosomal Recessive 3
Woolly Hair Autosomal Recessive 1 With Or Without Hypotrichosis	ARWH1
Hypotrichosis, Type 8

Hypotrichosis 11

HYPT11

Hypotrichosis, Type 11

Unilateral Retinoblastoma

Ectodermal Dysplasia 4, Hair/Nail Type

Pure Hair And Nail Ectodermal Dysplasia	ECTD4
Ectodermal Dysplasia, Pure Hair-Nail Type	Ectodermal Dysplasia, 'Pure' Hair/Nail Type
Hned	Hair-Nail Ectodermal Dysplasia
Phned	Ectodermal Dysplasia Pure Hair-Nail Type
Ectodermal Dysplasia, 'Pure' Hair-Nail Type	Dysplasia, Ectodermal, Type 4, Hair/Nail

Familial Woolly Hair Syndrome

Wooly Hair	Familial Wooly Hair Syndrome
Hereditary Woolly Hair Syndrome	Hereditary Wooly Hair Syndrome
Woolly Hair	Syndrome With Woolly Hair
Wooly Hair Syndrome

Woolly Hair, Autosomal Dominant

Autosomal Dominant Woolly Hair	ADWH
Woolly Hair Autosomal Dominant

Woolly Hair, Autosomal Recessive 3

ARWH3	Woolly Hair, Autosomal Recessive 3, With Hypotrichosis
Autosomal Recessive Woolly Hair 3	Woolly Hair Autosomal Recessive 3

Hypotrichosis, Congenital, With Juvenile Macular Dystrophy

HJMD	Congenital Hypotrichosis With Juvenile Macular Dystrophy
Hypotrichosis With Cone-Rod Dystrophy	Hypotrichosis With Juvenile Macular Dystrophy
Juvenile Macular Degeneration And Hypotrichosis	Juvenile Macular Dystrophy And Congenital Hypotrichosis
Hypotrichosis With Juvenile Macular Degeneration	Hypotrichosis Congenital With Juvenile Macular Dystrophy

Hair Disease

Hair Diseases	Hair Anomaly
Hair Disorder	Hair Problems

Hypotrichosis 13

HYPT13	Hypotrichosis With Woolly Hair
Hypotrichosis, Type 13

Hypotrichosis 4

HYPT4	Marie Unna Hereditary Hypotrichosis 1
Muhh1	Hypotrichosis, Marie Unna Type, 1
Hypotrichosis Marie Unna 1	Marie Unna Hereditary Hypotrichosis Type 1
Hypotrichosis, Hereditary, Marie Unna Type, 1	Hypotrichosis, Type 4

T-Cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy

Winged Helix Deficiency	Alymphoid Cystic Thymic Dysgenesis
Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy Syndrome	Pignata Guarino Syndrome
TIDAND	T-Cell Immunodeficiency, Congenital Alopecia And Nail Dystrophy
Congenital Alopecia And Nail Dystrophy Associated With Severe Functional T-Cell Immunodeficiency	Severe Combined Immunodeficiency Due To Foxn1 Deficiency
Foxn1 Deficiency	Nude/Scid
Nude/Severe Combined Immunodeficiency	Scid Due To Foxn1 Deficiency
Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy

Hypotrichosis

Hypotrichosis 2

HYPT2	Hypotrichosis Simplex Of The Scalp 1
Htss1	Htss
Hypotrichosis, Spanish Type	Spanish Type Hypotrichosis
Hypotrichosis Spanish Type	Hypotrichosis, Type 2
Hypotrichosis Simplex Of Scalp

Monilethrix

Beaded Hair	MNLIX
Nodose Hair	Moniliform Hair Syndrome

Hypotrichosis Simplex

Hereditary Hypotrichosis Simplex

Hhs

Atrichia With Papular Lesions

Papular Atrichia	APL
Congenital Atrichia

Bilateral Retinoblastoma

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Hypotrichosis 3

HYPT3	Hypotrichosis Simplex Of The Scalp 2
Htss2	Hypotrichosis, Type 3

Hypotrichosis 7

Woolly Hair, Autosomal Recessive 2, With Or Without Hypotrichosis	HYPT7
Hypotrichosis, Localized, Autosomal Recessive 2	Lah2
Ah	Total Hypotrichosis, Mari Type
Wh/Ht	Hypotrichosis, Autosomal Recessive
Hypotrichosis, Total, Mari Type	Woolly Hair, Autosomal Recessive 2 With Or Without Hypotrichosis
Total Mari Type Hypotrichosis	Alopecia Universalis Congenita, Mari Type
Mari Type Alopecia Universalis Congenita	Autosomal Recessive Hypotrichosis
Autosomal Recessive Localized Hypotrichosis	Autosomal Recessive Woolly Hair With Or Without Hypotrichosis
Htl	Hypotrichoses
Hypotrichosis	Lah
Alopecia Universalis Congenita Mari Type	Hypotrichosis Autosomal Recessive
Hypotrichosis Localized Autosomal Recessive 2	Total Hypotrichosis Mari Type
Woolly Hair Autosomal Recessive 2	ARWH2
Woolly Hair Autosomal Recessive 2 With Or Without Hypotrichosis

Hypotrichosis 6

HYPT6	Lah1
Hypotrichosis, Localized, Autosomal Recessive	Monilethrix-Like Hypotrichosis
Hypotrichosis, Localized, Autosomal Recessive 1	Lah
Htl	Autosomal Recessive Localized Hypotrichosis
Hypotrichosis Localized Autosomal Recessive	Hypotrichosis Localized Autosomal Recessive 1
Hypotrichosis, Type 6

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS07761	LPAR6 Human Pre-designed siRNA Set A	/	Unkown
HY-RS07762	Lpar6 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS07763	Lpar6 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LPAR6	VGNC	VGNC:74292
Rattus norvegicus	LPAR6	RGD	RGD:1595950
Bos taurus	LPAR6	VGNC	VGNC:30960
Felis catus	LPAR6	VGNC	VGNC:82329
Mus musculus	LPAR6	MGD	MGI:1914418
Canis familiaris	LPAR6	VGNC	VGNC:42747

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