CORIN - corin, serine peptidase Gene

Also Known as CRN; ATC2; Lrp4; PEE5; TMPRSS10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10699

About CORIN

Cytogenetic location: 4p12 Genomic coordinates (GRCh38): 4:47,594,001-47,838,067 (from NCBI)

This gene has 11 transcripts (splice variants), 202 orthologues and is associated with 2 phenotypes. Biased expression in heart (RPKM 20.5), skin (RPKM 3.4) and 2 other tissues.

Summary

This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

CORIN Products (3)

mRNA	Protein	Name
NM_001278585.2	NP_001265514.1	atrial natriuretic peptide-converting enzyme isoform 2
NM_001278586.2	NP_001265515.1	atrial natriuretic peptide-converting enzyme isoform 3
NM_006587.4	NP_006578.2	atrial natriuretic peptide-converting enzyme isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables endopeptidase activity	IMP IMP: Inferred from mutant phenotype	20489134	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables serine-type endopeptidase activity	IDA IDA: Inferred from direct assay	10880574	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in female pregnancy	IMP IMP: Inferred from mutant phenotype	22437503	GOA
involved in peptide hormone processing	IDA IDA: Inferred from direct assay	10880574	GOA
involved in regulation of systemic arterial blood pressure by atrial natriuretic peptide	IMP IMP: Inferred from mutant phenotype	22437503	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	21518754	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CORIN Protein Structure

Ldl_recept_a

SRCR_2

Trypsin

0
200
400
600
800
1042 a.a.

Protein Preferred Names	Protein Names
atrial natriuretic peptide-converting enzyme	heart-specific serine proteinase ATC2

CORIN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CORIN	Q9Y5Q5	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	CORIN	Q9Y5Q5	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	CORIN	Q9Y5Q5	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	CORIN	Q9Y5Q5	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	CORIN	Q9Y5Q5	CLDN5	Homo sapiens	O00501	Y2H Array	32296183
Intra	CORIN	Q9Y5Q5	CLDN5	Homo sapiens	O00501	Y2H Prey Pooling	32296183
Intra	CORIN	Q9Y5Q5	EMP1	Homo sapiens	P54849	Y2H Array	32296183
Intra	CORIN	Q9Y5Q5	EMP1	Homo sapiens	P54849	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

CORIN Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89589	Corin Antibody (YA8933)	WB, IP, ELISA	human

Related Diseases

Diseases	Alias
Preeclampsia/Eclampsia 5	PEE5 Pre-Eclampsia/Eclampsia 5 Gestational Proteinuric Hypertension Preeclampsia/Eclampsia, Type 5
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia
Eclampsia	Eclampsia In Puerperium Postpartum Eclampsia Eclampsia, Postpartum Puerperal Eclampsia
Cone-Rod Dystrophy 12	CORD12 Dystrophy, Cone-Rod, Type 12
St. Louis Encephalitis	Saint Louis Encephalitis Neuroinvasive St. Louis Encephalitis Virus Infection Encephalitis, St. Louis Neuroinvasive Saint Louis Encephalitis Virus Infection St. Louis Encephalitis Virus Infection St. Louis Encephalitis Virus Neuroinvasive Disease St. Louis Viral Disease Type C Lethargic Encephalitis Encephalitis Type C
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111048	Corin	Inhibitor	98.16%	Unkown
HY-RS03047	CORIN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17975	Corin Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24446	Corin Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CORIN	VGNC	VGNC:27619
Felis catus	CORIN	VGNC	VGNC:78471
Macaca mulatta	CORIN	VGNC	VGNC:71212
Canis familiaris	CORIN	VGNC	VGNC:39526
Rattus norvegicus	CORIN	RGD	RGD:727887
Mus musculus	CORIN	MGD	MGI:1349451
Others	CORIN	NCBI