TMEM9 - transmembrane protein 9 Gene

Also Known as DERM4; TMEM9A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 252839

About TMEM9

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:201,134,772-201,171,558 (from NCBI)

This gene has 11 transcripts (splice variants), 206 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 25.4), thyroid (RPKM 25.3) and 25 other tissues.

Summary

Involved in intracellular pH reduction; positive regulation of canonical Wnt signaling pathway; and proton-transporting V-type ATPase complex assembly. Located in bounding membrane of organelle; intercellular bridge; and mitotic spindle. [provided by Alliance of Genome Resources, Apr 2022]

TMEM9 Products (9)

mRNA Protein Name
NM_001288564.2 NP_001275493.1 proton-transporting V-type ATPase complex assembly regulator TMEM9 isoform a precursor
NM_001288565.2 NP_001275494.1 proton-transporting V-type ATPase complex assembly regulator TMEM9 isoform a precursor
NM_001288566.2 NP_001275495.1 proton-transporting V-type ATPase complex assembly regulator TMEM9 isoform a precursor
NM_001288567.2 NP_001275496.1 proton-transporting V-type ATPase complex assembly regulator TMEM9 isoform a precursor
NM_001288568.2 NP_001275497.1 proton-transporting V-type ATPase complex assembly regulator TMEM9 isoform a precursor
NM_001288569.2 NP_001275498.1 proton-transporting V-type ATPase complex assembly regulator TMEM9 isoform a precursor
NM_001288570.2 NP_001275499.1 proton-transporting V-type ATPase complex assembly regulator TMEM9 isoform b precursor
NM_001288571.2 NP_001275500.1 proton-transporting V-type ATPase complex assembly regulator TMEM9 isoform c precursor
NM_016456.5 NP_057540.1 proton-transporting V-type ATPase complex assembly regulator TMEM9 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
30374053 GOA
Biological Process GO Annotation Evidence References Source
involved in endosomal lumen acidification IDA
IDA: Inferred from direct assay
30374053 GOA
involved in lysosomal lumen acidification IDA
IDA: Inferred from direct assay
30374053 GOA
involved in positive regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
30374053 GOA
involved in proton-transporting V-type ATPase complex assembly IDA
IDA: Inferred from direct assay
30374053 GOA
Cellular Component GO Annotation Evidence References Source
located in late endosome IDA
IDA: Inferred from direct assay
12359240 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
30374053 GOA
located in lysosome IDA
IDA: Inferred from direct assay
12359240 GOA
located in multivesicular body membrane IDA
IDA: Inferred from direct assay
30374053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM9 Protein Structure

Tmemb_9

Tmemb_9: TMEM9 (35 - 182)

  • 0
  • 100
  • 183 a.a.
Protein Preferred Names Protein Names

proton-transporting V-type ATPase complex assembly regulator TMEM9

  • dermal papilla-derived protein 4

TMEM9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMEM9 Q9P0T7 PGAP2 Homo sapiens Q9UHJ9-5
Validated Y2H
32296183
Intra
TMEM9 Q9P0T7 STX6 Homo sapiens O43752
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Snail Allergy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14746 TMEM9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TMEM9 RGD RGD:1307922
Mus musculus TMEM9 MGD MGI:1913491
Macaca mulatta TMEM9 VGNC VGNC:79162
Bos taurus TMEM9 VGNC VGNC:36125
Felis catus TMEM9 VGNC VGNC:66370
Others TMEM9 NCBI