2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor
  3. Glucocorticoid Receptor
  4. Dexamethasone phosphate

Dexamethasone phosphate  (Synonyms: Dexamethasone 21-phosphate)

Cat. No.: HY-B1829 Purity: 98.89%
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Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is a biologically inactive compound which undergoes dephosphorylation by intra-erythrocyte enzymes. The active metabolite, Dexamethasone, is then released into the circulation by simple passive diffusion through cell membranes. Dexamethasone phosphate disodium-encapsulated erythrocyte has the potential for steroid-dependent ulcerative colitis research.

For research use only. We do not sell to patients.

CAS No. : 312-93-6

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Based on 10 publication(s) in Google Scholar

Other Forms of Dexamethasone phosphate:

Dexamethasone phosphate Related Antibodies

Top Publications Citing Use of Products

    Dexamethasone phosphate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 8:e17129.  [Abstract]

    DXMS (2 mg/kg; twice daily; ip). Kaplan-Meier survival curves over a 7-day period comparing the Sham, CLP septic group, Emodin treatment group, and DXMS treatment group.

    Dexamethasone phosphate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 8:e17129.  [Abstract]

    DXMS (2 mg/kg; twice daily; ip). Histopathological images showing tissue morphology and injury in the lung, liver, spleen, and kidney across the four experimental groups.

    Dexamethasone phosphate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Dec 2:244:117586.  [Abstract]

    Masson-stained images of mice tibias. Masson staining indicated a marked decrease in new bone formation in DEX (Dexamethasone phosphate disodium, 1 mg/kg; i.p.; Once daily for 8 weeks)-treated mice.

    Dexamethasone phosphate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Dec 2:244:117586.  [Abstract]

    DEX (1 μM; 24 h). The mRNA expression levels of p53, p21 and p16 of bone ECs were detected via qRT-PCR.

    Dexamethasone phosphate purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Dec 2:244:117586.  [Abstract]

    DEX (1 μM; 24 h). The protein expression of p53, p21, p16 and GAPDH was detected via Western blot and quantitative analysis.

    Dexamethasone phosphate purchased from MedChemExpress. Usage Cited in: Sci Rep. 2025 Oct 14;15(1):35928.  [Abstract]

    Comparison of C3 mRNA levels between non-reactive astrocytes (Lucid), LPS-induced reactive astrocytes (LPS), and Dexamethasone phosphate disodium (DEX, 100 nM; 24 h)-reversed reactive astrocytes (LPS + DEX), with results normalized to the Lucid group (one-way ANOVA followed by Bonferroni post hoc test).

    Dexamethasone phosphate purchased from MedChemExpress. Usage Cited in: MedComm. 2023 Jun 5;4(3):e293.  [Abstract]

    Dexamethasone phosphate disodium (DXM, 5 mg/kg; i.p.; single dose) significantly alleviated tissue damage in acute lung injury (ALI).

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    Description

    Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is a biologically inactive compound which undergoes dephosphorylation by intra-erythrocyte enzymes. The active metabolite, Dexamethasone, is then released into the circulation by simple passive diffusion through cell membranes. Dexamethasone phosphate disodium-encapsulated erythrocyte has the potential for steroid-dependent ulcerative colitis research[1].

    Clinical Trial
    Molecular Weight

    472.44

    Formula

    C22H30FO8P
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@]4(O)C(COP(O)(O)=O)=O)=C1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    DMSO : 5 mg/mL (10.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1167 mL 10.5834 mL 21.1667 mL
    5 mM 0.4233 mL 2.1167 mL 4.2333 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    Please enter the basic information of animal experiments:

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    Working solution concentration: mg/mL
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.1167 mL 10.5834 mL 21.1667 mL 52.9168 mL
    5 mM 0.4233 mL 2.1167 mL 4.2333 mL 10.5834 mL
    10 mM 0.2117 mL 1.0583 mL 2.1167 mL 5.2917 mL
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    Dexamethasone phosphate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Dexamethasone312-93-6Dexamethasone 21-phosphateGlucocorticoid ReceptorDephosphorylationintra-erythrocyte enzymeserythrocytesteroidulcerative colitisInhibitorinhibitorinhibit

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