AMIGO1 - adhesion molecule with Ig like domain 1 Gene

Also Known as ALI2; AMIGO; AMIGO-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57463

About AMIGO1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,504,178-109,509,727 (from NCBI)

This gene has 2 transcripts (splice variants), 248 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 9.3), adrenal (RPKM 6.7) and 24 other tissues.

Summary

Predicted to enable Potassium Channel regulator activity. Predicted to be involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and nervous system development. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in dendrite and neuronal cell body membrane. Predicted to be integral component of membrane. Predicted to colocalize with voltage-gated Potassium Channel complex. [provided by Alliance of Genome Resources, Apr 2022]

AMIGO1 Products (1)

mRNA	Protein	Name
NM_020703.4	NP_065754.2	amphoterin-induced protein 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AMIGO1 Protein Structure

LRR_8

LRR_1

V-set

0
100
200
300
400
493 a.a.

Protein Preferred Names	Protein Names
amphoterin-induced protein 1	alivin-2

AMIGO1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AMIGO1	Q86WK6	SLC38A7	Homo sapiens	Q9NVC3	Validated Y2H	32296183
Intra	AMIGO1	Q86WK6	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183
Intra	AMIGO1	Q86WK6	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	AMIGO1	Q86WK6	PLPP6	Homo sapiens	Q8IY26	Validated Y2H	32296183
Intra	AMIGO1	Q86WK6	LMO3	Homo sapiens	Q8TAP4-4	Validated Y2H	32296183
Intra	AMIGO1	Q86WK6	TNMD	Homo sapiens	Q9H2S6-2	Validated Y2H	32296183
Intra	AMIGO1	Q86WK6	PGAP2	Homo sapiens	Q9UHJ9-5	Validated Y2H	32296183
Intra	AMIGO1	Q86WK6	SLC41A1	Homo sapiens	Q8IVJ1	Validated Y2H	32296183
Intra	AMIGO1	Q86WK6	PROM2	Homo sapiens	Q8N271	Validated Y2H	32296183
Intra	AMIGO1	Q86WK6	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	AMIGO1	Q86WK6	FAM3C	Homo sapiens	Q92520	Validated Y2H	32296183
Intra	AMIGO1	Q86WK6	HHATL	Homo sapiens	Q9HCP6	Validated Y2H	32296183
Intra	AMIGO1	Q86WK6	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183
Intra	AMIGO1	Q86WK6	TMEM79	Homo sapiens	Q9BSE2	Validated Y2H	32296183
Intra	AMIGO1	Q86WK6	SELENOK	Homo sapiens	Q9Y6D0	Validated Y2H	32296183
Intra	AMIGO1	Q86WK6	SLC38A1	Homo sapiens	Q9H2H9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Tungiasis	Tunga Penetrans Infestation Chigger Flea S Penetrans Sarcopsylla Penetrans T Penetrans Tunga Penetrans Sand-Flea Infestation Jiggers Infestation Chigoe Infestation Jigger Disease
Developmental And Epileptic Encephalopathy 26	DEE26 Epileptic Encephalopathy, Early Infantile, 26 Eiee26 Early Infantile Epileptic Encephalopathy 26 Developmental And Epileptic Encephalopathy, 26 Encephalopathy, Epileptic, Early Infantile, Type 26

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00657	AMIGO1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	AMIGO1	MGD	MGI:2653612
Felis catus	AMIGO1	VGNC	VGNC:59765
Rattus norvegicus	AMIGO1	RGD	RGD:1303079
Bos taurus	AMIGO1	VGNC	VGNC:25865
Canis familiaris	AMIGO1	VGNC	VGNC:37831
Macaca mulatta	AMIGO1	VGNC	VGNC:69653
Others	AMIGO1	NCBI