HHATL - hedgehog acyltransferase like Gene

Also Known as GUP1; OACT3; C3orf3; MBOAT3; MSTP002

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57467

About HHATL

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:42,692,663-42,702,798 (from NCBI)

This gene has 12 transcripts (splice variants), 248 orthologues and 1 paralogue. Restricted expression toward heart (RPKM 165.4).

Summary

Predicted to enable Acyltransferase activity. Predicted to be involved in negative regulation of N-terminal protein palmitoylation. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

HHATL Products (1)

mRNA Protein Name
NM_020707.4 NP_065758.3 protein-cysteine N-palmitoyltransferase HHAT-like protein

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11374908 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HHATL Protein Structure

MBOAT

MBOAT: MBOAT, membrane-bound O-acyltransferase family (186 - 406)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 504 a.a.
Protein Preferred Names Protein Names

protein-cysteine N-palmitoyltransferase HHAT-like protein

  • GUP1 glycerol uptake/transporter homolog

HHATL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HHATL Q9HCP6 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra
HHATL Q9HCP6 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra
HHATL Q9HCP6 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
HHATL Q9HCP6 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
HHATL Q9HCP6 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
HHATL Q9HCP6 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
HHATL Q9HCP6 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
HHATL Q9HCP6 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
HHATL Q9HCP6 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra
HHATL Q9HCP6 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra
HHATL Q9HCP6 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
HHATL Q9HCP6 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
HHATL Q9HCP6 SUSD3 Homo sapiens Q96L08
Y2H Array
32296183
Intra
HHATL Q9HCP6 SUSD3 Homo sapiens Q96L08
Y2H Prey Pooling
32296183
Intra
HHATL Q9HCP6 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
HHATL Q9HCP6 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
HHATL Q9HCP6 MILR1 Homo sapiens Q7Z6M3
Y2H Array
32296183
Intra
HHATL Q9HCP6 MILR1 Homo sapiens Q7Z6M3
Y2H Prey Pooling
32296183
Intra
HHATL Q9HCP6 AMIGO1 Homo sapiens Q86WK6
Y2H Prey Pooling
32296183
Intra
HHATL Q9HCP6 AMIGO1 Homo sapiens Q86WK6
Y2H Array
32296183
Intra
HHATL Q9HCP6 FKBP7 Homo sapiens Q9Y680
Y2H Prey Pooling
32296183
Intra
HHATL Q9HCP6 FKBP7 Homo sapiens Q9Y680
Validated Y2H
32296183
Intra
HHATL Q9HCP6 FKBP7 Homo sapiens Q9Y680
Y2H Array
32296183
Intra
HHATL Q9HCP6 PVR Homo sapiens P15151
Y2H Array
32296183
Intra
HHATL Q9HCP6 PVR Homo sapiens P15151
Y2H Prey Pooling
32296183
Intra
HHATL Q9HCP6 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
HHATL Q9HCP6 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
HHATL Q9HCP6 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
HHATL Q9HCP6 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
HHATL Q9HCP6 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
HHATL Q9HCP6 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nemaline Myopathy 8

  • NEM8

  • Nemaline Myopathy 8, Autosomal Recessive

  • Myopathy, Nemaline, Type 8
Cardiomyopathy, Dilated, 1e

  • Left Ventricular Noncompaction 9

  • Left Ventricular Noncompaction 5

  • Dilated Cardiomyopathy 1e

  • Dilated Cardiomyopathy 1s

  • CMD1E

  • Cdcd2

  • Cardiomyopathy, Dilated, 1y

  • CMD1Y

  • Cardiomyopathy, Dilated, 1s

  • CMD1S

  • Dilated Cardiomyopathy 1y

  • Dilated Cardiomyopathy With Conduction Defect 2

  • Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia

  • Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia

  • Cardiomyopathy, Dilated, With Conduction Defect 2

  • Cardiomyopathy Dilated With Conduction Defect Type 2

  • Cardiomyopathy, Dilated 1e

  • Cardiomyopathy, Dilated 1s

  • Cardiomyopathy, Dilated 1y

  • Left Ventricular Non-Compaction 5

  • LVNC5

  • Left Ventricular Non-Compaction 9

  • LVNC9

  • Cardiomyopathy, Dilated, Type 1e

  • Cardiomyopathy, Dilated, Type 1s

  • Cardiomyopathy, Dilated, Type 1y
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease

  • Polycystic Kidney Disease 2

  • PKD2

  • Polycystic Kidney Disease, Adult, Type Ii

  • Apkd2

  • Polycystic Kidney Disease, Type 2

  • Adpkd2

  • Adult Polycystic Kidney Disease Type 2

  • Autosomal Dominant Polycystic Kidney Disease 2

  • Pkd-2

  • Polycystic Kidney Disease Adult Type Ii

  • Polycystic Kidney Type 2 Autosomal Dominant Disease

  • Kidney Disease, Polycystic, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06158 HHATL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22552 Hhatl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus HHATL VGNC VGNC:29838
Macaca mulatta HHATL VGNC VGNC:73161
Canis familiaris HHATL VGNC VGNC:49672
Felis catus HHATL VGNC VGNC:62808
Rattus norvegicus HHATL RGD RGD:1311911
Mus musculus HHATL MGD MGI:1922020
Others HHATL NCBI