SLC38A1 - solute carrier family 38 member 1 Gene

Also Known as ATA1; NAT2; SAT1; SNAT1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81539

About SLC38A1

Cytogenetic location: 12q13.11 Genomic coordinates (GRCh38): 12:46,183,063-46,269,043 (from NCBI)

This gene has 11 transcripts (splice variants), 161 orthologues and 15 paralogues. Broad expression in lymph node (RPKM 24.7), thyroid (RPKM 21.1) and 23 other tissues.

Summary

Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001 [PubMed 11325958]).[supplied by OMIM, Mar 2008]

SLC38A1 Products (6)

mRNA Protein Name
NM_001077484.2 NP_001070952.1 sodium-coupled neutral amino acid symporter 1 isoform 1
NM_001278387.2 NP_001265316.1 sodium-coupled neutral amino acid symporter 1 isoform 1
NM_001278388.2 NP_001265317.1 sodium-coupled neutral amino acid symporter 1 isoform 1
NM_001278389.2 NP_001265318.1 sodium-coupled neutral amino acid symporter 1 isoform 1
NM_001278390.1 NP_001265319.1 sodium-coupled neutral amino acid symporter 1 isoform 2
NM_030674.4 NP_109599.3 sodium-coupled neutral amino acid symporter 1 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
23137377 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC38A1 Protein Structure

Aa_trans

Aa_trans: Transmembrane amino acid transporter protein (70 - 470)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 487 a.a.
Protein Preferred Names Protein Names

sodium-coupled neutral amino acid symporter 1

sodium-coupled neutral amino acid transporter 1

  • N-system amino acid transporter 2

SLC38A1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC38A1 Q9H2H9 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra
SLC38A1 Q9H2H9 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra
SLC38A1 Q9H2H9 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra
SLC38A1 Q9H2H9 TMPPE Homo sapiens Q6ZT21
Y2H Array
32296183
Intra
SLC38A1 Q9H2H9 TMPPE Homo sapiens Q6ZT21
Y2H Prey Pooling
32296183
Intra
SLC38A1 Q9H2H9 SLC13A4 Homo sapiens Q9UKG4
Y2H Prey Pooling
32296183
Intra
SLC38A1 Q9H2H9 SLC13A4 Homo sapiens Q9UKG4
Validated Y2H
32296183
Intra
SLC38A1 Q9H2H9 SLC13A4 Homo sapiens Q9UKG4
Y2H Array
32296183
Intra
SLC38A1 Q9H2H9 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
SLC38A1 Q9H2H9 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
SLC38A1 Q9H2H9 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
SLC38A1 Q9H2H9 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
SLC38A1 Q9H2H9 PDCD1LG2 Homo sapiens Q9BQ51
Y2H Array
32296183
Intra
SLC38A1 Q9H2H9 PDCD1LG2 Homo sapiens Q9BQ51
Y2H Prey Pooling
32296183
Intra
SLC38A1 Q9H2H9 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
SLC38A1 Q9H2H9 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
SLC38A1 Q9H2H9 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
SLC38A1 Q9H2H9 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
SLC38A1 Q9H2H9 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
SLC38A1 Q9H2H9 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
SLC38A1 Q9H2H9 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
SLC38A1 Q9H2H9 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
SLC38A1 Q9H2H9 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
SLC38A1 Q9H2H9 AMIGO1 Homo sapiens Q86WK6
Y2H Array
32296183
Intra
SLC38A1 Q9H2H9 AMIGO1 Homo sapiens Q86WK6
Y2H Prey Pooling
32296183
Intra
SLC38A1 Q9H2H9 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
SLC38A1 Q9H2H9 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
SLC38A1 Q9H2H9 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra
SLC38A1 Q9H2H9 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra
SLC38A1 Q9H2H9 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra
SLC38A1 Q9H2H9 FATE1 Homo sapiens Q969F0
Validated Y2H
25416956
Intra
SLC38A1 Q9H2H9 FATE1 Homo sapiens Q969F0
Y2H Array
32296183
Intra
SLC38A1 Q9H2H9 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
25416956
Intra
SLC38A1 Q9H2H9 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
32296183
Intra
SLC38A1 Q9H2H9 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
SLC38A1 Q9H2H9 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Klatskin'S Tumor

  • Klatskin Tumor

  • Hilar Cholangiocarcinoma

  • Perihilar Cholangiocarcinoma

  • Hilar Cholangiocellular Carcinoma

  • Klatskin Tumour

  • Klatskin'S Tumour

  • Perihilar Extrahepatic Bile Duct Carcinoma

  • Hilar Cca

  • Adenocarcinoma Of Hepatic Duct

  • Klatskin Tumour Of Biliary Tree
Persistent Fetal Circulation Syndrome

  • Persistent Fetal Circulation

  • Fetal Circulation

  • Persistent Pulmonary Hypertension Of The Newborn

  • Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins

  • Persistent Foetal Circulation

  • Persistent Foetal Circulation Syndrome

  • Pfc - [Persistent Fetal Circulation] Syndrome

  • Pphn - [Persistent Pulmonary Hypertension Of The Newborn]

  • Newborn Pulmonary Hypertension

  • Primary Pulmonary Hypertension Of Newborn
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13217 SLC38A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20218 Slc38a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26725 Slc38a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SLC38A1 VGNC VGNC:77468
Mus musculus SLC38A1 MGD MGI:2145895
Canis familiaris SLC38A1 VGNC VGNC:46390
Bos taurus SLC38A1 VGNC VGNC:34846
Rattus norvegicus SLC38A1 RGD RGD:69645
Felis catus SLC38A1 VGNC VGNC:65342
Others SLC38A1 NCBI