SLC38A1 - solute carrier family 38 member 1 Gene

Homo sapiens

Also known as ATA1; NAT2; SAT1; SNAT1

Gene ID: 81539 | Gene type: protein coding

About SLC38A1

Cytogenetic location: 12q13.11 Genomic coordinates (GRCh38): 12:46,183,063-46,269,043 (from NCBI)

This gene has 11 transcripts (splice variants), 161 orthologues and 15 paralogues. Broad expression in lymph node (RPKM 24.7), thyroid (RPKM 21.1) and 23 other tissues.

Summary

Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001 [PubMed 11325958]).[supplied by OMIM, Mar 2008]

SLC38A1 Products(6)

mRNA	Protein	Name
NM_001077484.2	NP_001070952.1	sodium-coupled neutral amino acid symporter 1 isoform 1
NM_001278387.2	NP_001265316.1	sodium-coupled neutral amino acid symporter 1 isoform 1
NM_001278388.2	NP_001265317.1	sodium-coupled neutral amino acid symporter 1 isoform 1
NM_001278389.2	NP_001265318.1	sodium-coupled neutral amino acid symporter 1 isoform 1
NM_001278390.1	NP_001265319.1	sodium-coupled neutral amino acid symporter 1 isoform 2
NM_030674.4	NP_109599.3	sodium-coupled neutral amino acid symporter 1 isoform 1

SLC38A1 Protein Structure

Aa_trans

0
100
200
300
400
487 a.a.

Protein Preferred Names

Protein Names

sodium-coupled neutral amino acid symporter 1

sodium-coupled neutral amino acid transporter 1

N-system amino acid transporter 2

Related Diseases

Diseases

Alias

Klatskin'S Tumor

Klatskin Tumor	Hilar Cholangiocarcinoma
Perihilar Cholangiocarcinoma	Hilar Cholangiocellular Carcinoma
Klatskin Tumour	Klatskin'S Tumour
Perihilar Extrahepatic Bile Duct Carcinoma	Hilar Cca
Adenocarcinoma Of Hepatic Duct	Klatskin Tumour Of Biliary Tree

Persistent Fetal Circulation Syndrome

Persistent Fetal Circulation	Fetal Circulation
Persistent Pulmonary Hypertension Of The Newborn	Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Persistent Foetal Circulation	Persistent Foetal Circulation Syndrome
Pfc - [Persistent Fetal Circulation] Syndrome	Pphn - [Persistent Pulmonary Hypertension Of The Newborn]
Newborn Pulmonary Hypertension	Primary Pulmonary Hypertension Of Newborn

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13217	SLC38A1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC38A1	VGNC	VGNC:77468
Mus musculus	SLC38A1	MGD	MGI:2145895
Canis familiaris	SLC38A1	VGNC	VGNC:46390
Bos taurus	SLC38A1	VGNC	VGNC:34846
Rattus norvegicus	SLC38A1	RGD	RGD:69645
Felis catus	SLC38A1	VGNC	VGNC:65342
Others	SLC38A1	NCBI

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