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Cat. No.: HY-149650

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TLR4 agonist-1

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

TLR4 agonist-1 (compound 17a) is a potent agonist of Toll-like Receptor 4 (TLR4), and induces the generation of MIP-1β in RAW 264.7 and MM6 cells.

For research use only. We do not sell to patients.

CAS No.: 2374139-51-0
Formula: C₈₁H₁₅₈N₃O₁₅P
Molecular Weight:1445.11

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

TLR4 agonist-1 Chemical Structure

CAS No.: 2374139-51-0

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Biological Activity

Description

TLR4 agonist-1 (compound 17a) is a potent agonist of Toll-like Receptor 4 (TLR4), and induces the generation of MIP-1β in RAW 264.7 and MM6 cells^[1].

All Toll-like Receptor (TLR) Isoforms :

Chemical Information

CAS No. 2374139-51-0
Molecular Weight 1445.11
Formula C₈₁H₁₅₈N₃O₁₅P
SMILES

OC[C@H]1O[C@@H](OC[C@@H](C(O)=O)NC(C[C@H](OCCCCCCCCCC)CCCCCCCCCCC)=O)[C@H](NC(C[C@H](OCCCCCCCCCC)CCCCCCCCCCC)=O)[C@H](NC(C[C@H](OCCCCCCCCCC)CCCCCCCCCCC)=O)[C@@H]1OP(O)(O)=O
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Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Int Immunopharmacol

Liquiritin attenuates IONI-induced trigeminal neuropathic pain via TLR4/MyD88-dependent modulation of microglial M1-like polarization. [Abstract]

2026 May 15:177:116554. PMID: 41880679

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Khalaf JK, et al. Diamino Allose Phosphates: Novel, Potent, and Highly Stable Toll-like Receptor 4 Agonists. J Med Chem. 2023;66(20):13900-13917. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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TLR4 agonist-1

1 Cited Publications

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TLR4 agonist-1

Publications Citing Use of MedChemExpress (MCE) TLR4 agonist-1

All Toll-like Receptor (TLR) Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

TLR4 agonist-1 Related Classifications

HY-149650 Related Classifications