TMEM176A - transmembrane protein 176A Gene

Also Known as GS188; MS4B1; HCA112

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55365

About TMEM176A

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:150,800,769-150,805,118 (from NCBI)

This gene has 11 transcripts (splice variants), 86 orthologues and 1 paralogue. Broad expression in liver (RPKM 172.7), kidney (RPKM 114.0) and 15 other tissues.

Summary

Predicted to be involved in negative regulation of dendritic cell differentiation. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM176A Products (1)

mRNA Protein Name
NM_018487.3 NP_060957.2 transmembrane protein 176A

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM176A Protein Structure

CD20

CD20: CD20-like family (57 - 214)

  • 0
  • 100
  • 200
  • 235 a.a.
Protein Preferred Names Protein Names

transmembrane protein 176A

  • hepatocellular carcinoma-associated antigen 112

TMEM176A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMEM176A Q96HP8 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
TMEM176A Q96HP8 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
TMEM176A Q96HP8 SGPL1 Homo sapiens O95470
Y2H Prey Pooling
32296183
Intra
TMEM176A Q96HP8 SGPL1 Homo sapiens O95470
Y2H Array
32296183
Intra
TMEM176A Q96HP8 SCD5 Homo sapiens Q9BSN4
Y2H Prey Pooling
32296183
Intra
TMEM176A Q96HP8 SCD5 Homo sapiens Q9BSN4
Validated Y2H
32296183
Intra
TMEM176A Q96HP8 SCD5 Homo sapiens Q9BSN4
Y2H Array
32296183
Intra
TMEM176A Q96HP8 CERS4 Homo sapiens Q9HA82
Y2H Prey Pooling
32296183
Intra
TMEM176A Q96HP8 CERS4 Homo sapiens Q9HA82
Validated Y2H
32296183
Intra
TMEM176A Q96HP8 CERS4 Homo sapiens Q9HA82
Y2H Array
32296183
Intra
TMEM176A Q96HP8 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra
TMEM176A Q96HP8 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra
TMEM176A Q96HP8 MTIF3 Homo sapiens Q9H2K0
Validated Y2H
32296183
Intra
TMEM176A Q96HP8 MTIF3 Homo sapiens Q9H2K0
Y2H Array
32296183
Intra
TMEM176A Q96HP8 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra
TMEM176A Q96HP8 KCNK5 Homo sapiens O95279
Y2H Prey Pooling
32296183
Intra
TMEM176A Q96HP8 KCNK5 Homo sapiens O95279
Y2H Array
32296183
Intra
TMEM176A Q96HP8 TIMMDC1 Homo sapiens Q9NPL8
Y2H Array
32296183
Intra
TMEM176A Q96HP8 TIMMDC1 Homo sapiens Q9NPL8
Y2H Prey Pooling
32296183
Intra
TMEM176A Q96HP8 TIMMDC1 Homo sapiens Q9NPL8
Validated Y2H
32296183
Intra
TMEM176A Q96HP8 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
TMEM176A Q96HP8 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
TMEM176A Q96HP8 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
TMEM176A Q96HP8 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
Intra
TMEM176A Q96HP8 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra
TMEM176A Q96HP8 LITAF Homo sapiens Q99732
Y2H Pooling
32814053
Intra
TMEM176A Q96HP8 LITAF Homo sapiens Q99732
Validated Y2H
32814053
Intra
TMEM176A Q96HP8 LITAF Homo sapiens Q99732
Y2H Array
32814053
Intra
TMEM176A Q96HP8 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
TMEM176A Q96HP8 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14684 TMEM176A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TMEM176A VGNC VGNC:66292
Rattus norvegicus TMEM176A RGD RGD:1310725
Mus musculus TMEM176A MGD MGI:1913308
Canis familiaris TMEM176A VGNC VGNC:47501
Bos taurus TMEM176A VGNC VGNC:36000
Macaca mulatta TMEM176A VGNC VGNC:81774
Others TMEM176A NCBI