SLC30A3 - solute carrier family 30 member 3 Gene

Also Known as ZNT3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7781

About SLC30A3

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,253,684-27,275,817 (from NCBI)

This gene has 10 transcripts (splice variants), 130 orthologues and 8 paralogues. Biased expression in testis (RPKM 9.2), brain (RPKM 7.3) and 1 other tissue.

Summary

Predicted to enable zinc ion transmembrane transporter activity. Involved in regulation of sequestering of zinc ion. Located in late endosome and synaptic vesicle. [provided by Alliance of Genome Resources, Apr 2022]

SLC30A3 Products (4)

mRNA Protein Name
NM_001318949.2 NP_001305878.1 zinc transporter 3 isoform b
NM_001318950.2 NP_001305879.1 zinc transporter 3 isoform c
NM_001318951.2 NP_001305880.1 zinc transporter 3 isoform c
NM_003459.5 NP_003450.2 zinc transporter 3 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables zinc ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
17349999 GOA
Biological Process GO Annotation Evidence References Source
involved in zinc ion import into lysosome IDA
IDA: Inferred from direct assay
17349999 GOA
involved in zinc ion transmembrane transport IDA
IDA: Inferred from direct assay
19521526 GOA
involved in zinc ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
26647834 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17349999 GOA
located in late endosome IDA
IDA: Inferred from direct assay
17349999 GOA
located in synaptic vesicle IDA
IDA: Inferred from direct assay
26647834 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC30A3 Protein Structure

Cation_efflux

Cation_efflux: Cation efflux family (76 - 371)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
Protein Preferred Names Protein Names

zinc transporter 3

  • solute carrier family 30 (zinc transporter), member 3

SLC30A3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC30A3 Q99726 NAALADL2 Homo sapiens Q58DX5
Y2H Prey Pooling
25416956
Intra
SLC30A3 Q99726 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
SLC30A3 Q99726 SLC30A8 Homo sapiens Q8IWU4
Y2H Array
32296183
Intra
SLC30A3 Q99726 SLC30A8 Homo sapiens Q8IWU4
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 TMEM242 Homo sapiens Q9NWH2
Validated Y2H
32296183
Intra
SLC30A3 Q99726 TMEM242 Homo sapiens Q9NWH2
Y2H Array
32296183
Intra
SLC30A3 Q99726 TMEM242 Homo sapiens Q9NWH2
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 SGPL1 Homo sapiens O95470
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 SGPL1 Homo sapiens O95470
Y2H Array
32296183
Intra
SLC30A3 Q99726 RTN3 Homo sapiens O95197-3
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 RTN3 Homo sapiens O95197-3
Y2H Array
32296183
Intra
SLC30A3 Q99726 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
SLC30A3 Q99726 SLC34A2 Homo sapiens O95436-2
Y2H Array
32296183
Intra
SLC30A3 Q99726 SLC34A2 Homo sapiens O95436-2
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
SLC30A3 Q99726 SLC30A4 Homo sapiens O14863
Anti Tag CoIP
26728129
Intra
SLC30A3 Q99726 SLC30A4 Homo sapiens O14863
Confocal
26728129
Intra
SLC30A3 Q99726 SLC30A4 Homo sapiens O14863
Crosslink
26728129
Intra
SLC30A3 Q99726 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
SLC30A3 Q99726 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
SLC30A3 Q99726 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
SLC30A3 Q99726 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra
SLC30A3 Q99726 FCRL3 Homo sapiens Q96P31-6
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 FCRL3 Homo sapiens Q96P31-6
Y2H Array
32296183
Intra
SLC30A3 Q99726 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
SLC30A3 Q99726 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
SLC30A3 Q99726 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
SLC30A3 Q99726 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
SLC30A3 Q99726 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
Intra
SLC30A3 Q99726 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra
SLC30A3 Q99726 CGRRF1 Homo sapiens Q99675
Y2H Array
32296183
Intra
SLC30A3 Q99726 CGRRF1 Homo sapiens Q99675
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 RNF19B Homo sapiens Q6ZMZ0
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 RNF19B Homo sapiens Q6ZMZ0
Y2H Array
32296183
Intra
SLC30A3 Q99726 OCIAD1 Homo sapiens Q9NX40
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 OCIAD1 Homo sapiens Q9NX40
Validated Y2H
32296183
Intra
SLC30A3 Q99726 OCIAD1 Homo sapiens Q9NX40
Y2H Array
32296183
Intra
SLC30A3 Q99726 CD40 Homo sapiens P25942
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 CD40 Homo sapiens P25942
Y2H Array
32296183
Intra
SLC30A3 Q99726 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra
SLC30A3 Q99726 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
SLC30A3 Q99726 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
SLC30A3 Q99726 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
SLC30A3 Q99726 SLC30A2 Homo sapiens Q9BRI3
Confocal
26728129
Intra
SLC30A3 Q99726 SLC30A2 Homo sapiens Q9BRI3
BiFC
25657003
Intra
SLC30A3 Q99726 SLC30A2 Homo sapiens Q9BRI3
Crosslink
26728129
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13181 SLC30A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SLC30A3 MGD MGI:1345280
Canis familiaris SLC30A3 VGNC VGNC:46348
Rattus norvegicus SLC30A3 RGD RGD:1359689
Bos taurus SLC30A3 VGNC VGNC:34808
Felis catus SLC30A3 VGNC VGNC:65309
Macaca mulatta SLC30A3 VGNC VGNC:77453
Others SLC30A3 NCBI