CCR1 - C-C motif chemokine receptor 1 Gene

Also Known as CKR1; CD191; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1230

About CCR1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:46,201,711-46,208,313 (from NCBI)

This gene has 1 transcript (splice variant), 159 orthologues, 23 paralogues and is associated with 1 phenotype. Broad expression in appendix (RPKM 27.8), spleen (RPKM 15.6) and 17 other tissues.

Summary

This gene encodes a member of the beta Chemokine Receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and Parasite. This gene and other Chemokine Receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

CCR1 Products (1)

mRNA	Protein	Name
NM_001295.3	NP_001286.1	C-C chemokine receptor type 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables C-C chemokine binding	IPI IPI: Inferred from physical interaction	7545673	GOA
enables C-C chemokine receptor activity	IDA IDA: Inferred from direct assay	10734056	GOA
enables chemokine (C-C motif) ligand 5 binding	IPI IPI: Inferred from physical interaction	7545673	GOA
enables chemokine (C-C motif) ligand 7 binding	IPI IPI: Inferred from physical interaction	7545673	GOA
enables chemokine receptor activity	IDA IDA: Inferred from direct assay	10660125	GOA
enables phosphatidylinositol phospholipase C activity	IDA IDA: Inferred from direct assay	10734056	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8699119	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in calcium ion transport	IDA IDA: Inferred from direct assay	10734056	GOA
involved in cell-cell signaling	IDA IDA: Inferred from direct assay	10734056	GOA
involved in chemokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	21403648	GOA
involved in exocytosis	IDA IDA: Inferred from direct assay	10734056	GOA
involved in immune response	IDA IDA: Inferred from direct assay	10734056	GOA
involved in intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	10734056	GOA
involved in monocyte chemotaxis	IDA IDA: Inferred from direct assay	29930254	GOA
involved in negative regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	21403648	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21403648	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	21403648	GOA
involved in positive regulation of calcium ion transport	IDA IDA: Inferred from direct assay	15764707	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	24056371	GOA
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	10734056	GOA
involved in positive regulation of monocyte chemotaxis	IDA IDA: Inferred from direct assay	18587271	GOA
involved in positive regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	21403648	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	10706735	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10660125	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	15001559	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCR1 Protein Structure

7tm_1

0
100
200
300
355 a.a.

Protein Preferred Names	Protein Names
C-C chemokine receptor type 1	C-C CKR-1 CC-CKR-1 CCR-1 LD78 receptor MIP-1alpha-R RANTES receptor RANTES-R chemokine (C-C motif) receptor 1 macrophage inflammatory protein 1-alpha receptor

CCR1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCR1	P32246	TMX1	Homo sapiens	Q9H3N1	Y2H Prey Pooling	32296183
Intra	CCR1	P32246	TMX1	Homo sapiens	Q9H3N1	Validated Y2H	32296183
Intra	CCR1	P32246	TMX1	Homo sapiens	Q9H3N1	Y2H Array	32296183
Intra	CCR1	P32246	CCL5	Homo sapiens	P13501	FACS	28381538
Intra	CCR1	P32246	PLP2	Homo sapiens	Q04941	Imaging	15474493
Intra	CCR1	P32246	PLP2	Homo sapiens	Q04941	Anti Tag CoIP	33961781
Intra	CCR1	P32246	CREB3	Homo sapiens	O43889-2	Anti Tag CoIP	15001559
Intra	CCR1	P32246	CREB3	Homo sapiens	O43889-2	IF	15001559
Intra	CCR1	P32246	CREB3	Homo sapiens	O43889-2	Y2H	15001559

Cross: Cross-species interaction Intra: Intraspecies interaction

CCR1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84260	CD191 Antibody (YA3957)	WB, FC, ELISA	Human
HY-P84260A	CD191 Antibody (YA3957)(PBS only)	WB, FC, ELISA	Human

Related Diseases

Diseases	Alias
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Disease Primary Immunodeficiency Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Disease Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Chromoblastomycosis	Chromomycosis Mossy Foot Disease Verrucous Dermatitis Fonseca Disease Pedroso Disease Drechslera Hawaiiensis Drechslera Infection
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Narcolepsy	Paroxysmal Sleep Gelineau Syndrome Narcoleptic Syndrome Narcolepsy-Cataplexy Syndrome Cataplexy And Narcolepsy Narcolepsy, Without Cataplexy Gelineau'S Syndrome Narcolepsy With Or Without Cataplexy Narcolepsy Nos
Corneal Ulcer	Cornea Ulcer Ulcerative Keratitis Corneal Ulcer Nos
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15545	AZD-4818		99.10%	Phase 2
HY-U00350	CCX354	Antagonist	99.18%	Phase 2
HY-120588	BI 639667	Antagonist	98.87%	Phase 1

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12080	BX471	Antagonist	99.98%	Unkown
HY-18611A	Abaucin	Antagonist	99.59%	Unkown
HY-12080A	BX471 hydrochloride	Antagonist	99.94%	Unkown
HY-18611	Abaucin hydrochloride	Antagonist	99.94%	Unkown
HY-103360	J-113863	Antagonist	≥99.0%	Unkown
HY-103355	YM022	Antagonist	99.87%	Unkown
HY-P4191A	Met-RANTES (human) acetate	Antagonist	99.39%	Unkown
HY-15546	BMS-817399	Antagonist	99.66%	Unkown
HY-124759	CCR1 antagonist 9	Antagonist	99.65%	Unkown
HY-P4191	Met-RANTES (human)	Antagonist	/	Unkown
HY-12079	CP-481715	Antagonist	/	Unkown
HY-124668	CCR1 antagonist 12	Antagonist	/	Unkown
HY-124668A	CCR1 antagonist 13	Antagonist	/	Unkown
HY-15544	CCR1 antagonist 10	Antagonist	/	Unkown
HY-185661	IBS007125	Inhibitor	/	Unkown
HY-171476	CP-865569	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CCR1	VGNC	VGNC:102023
Rattus norvegicus	CCR1	RGD	RGD:708446
Mus musculus	CCR1	MGD	MGI:104618
Macaca mulatta	CCR1	VGNC	VGNC:70737
Others	CCR1	NCBI