IBS007125
IBS007125 is a c-Maf inhibitor. IBS007125 does not alter the protein level or post-translational modification of c-Maf. IBS007125 inhibits some target genes of c-Maf (such as ITGB7 and CCR1). IBS007125 exerts anticancer effects on multiple myeloma expressing c-Maf. IBS007125 can be used for the research of multiple myeloma.
For research use only. We do not sell to patients.
- CAS No.: 2941099-67-6
- Formula: C14H18N4O
- Molecular Weight:258.32
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
CCR1 |
IBS007125 inhibits c-Maf transcriptional activity in HEK293T cells, as measured by reduced Ccl8 promoter-driven luciferase activity[1].
IBS007125 (18 h pre-incubation before LPS stimulation; 24 h LPS stimulation) selectively suppresses c-Maf-dependent cytokine (CCL8, IL-10) production without affecting c-Maf-independent TNFα production in LPS-stimulated BMDMs[1].
IBS007125 (0-20 μM; 5 days) suppresses proliferation of c-Maf-expressing RPMI-8226 multiple myeloma cells in a dose-dependent manner but does not affect proliferation of c-Maf-negative U266 multiple myeloma cells[1].
IBS007125 (10 μM; 2 days for c-Maf mRNA; 3 days for ITGB7 and CCR1 mRNA) modestly reduces c-Maf mRNA expression and significantly represses expression of the c-Maf target genes ITGB7 and CCR1 in RPMI-8226 multiple myeloma cells[1].
IBS007125 (10 μM; 2 days) does not affect c-Maf protein levels or post-translational modifications (as indicated by unaltered molecular weight) in RPMI-8226 multiple myeloma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:c-Maf-expressing RPMI-8226 multiple myeloma cells, c-Maf-negative U266 multiple myeloma cells
-
Concentration:0-20 μM
-
Incubation Time:5 days
-
Result:Suppressed proliferation of RPMI-8226 cells by nearly 50% at 10 μM but had no effect on U266 cell proliferation.
Suppressed RPMI-8226 cell proliferation in a dose-dependent manner with increasing inhibition up to 20 μM.
Did not affect U266 cell proliferation across all tested concentrations.
-
Cell Line:RPMI-8226 multiple myeloma cells
-
Concentration:10 μM
-
Incubation Time:2 days (c-Maf mRNA); 3 days (ITGB7 and CCR1 mRNA)
-
Result:Modestly repressed c-Maf mRNA levels.
Significantly repressed mRNA levels of the c-Maf target genes ITGB7 and CCR1.
Chemical Information
-
CAS No. 2941099-67-6
-
Molecular Weight 258.32
-
Formula C14H18N4O
-
SMILES
O=C1NC2=C(C=CC=C2)N=C1C/C(C(C)(C)C)=N/N
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz