CD191 Antibody (YA3957)
(Synonyms: CCR1; CKR1; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1)CD191 Antibody (YA3957) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD191.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:400 | 1:10000 |
Product Details
CD191 Antibody (YA3957) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD191.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 41 kDa0
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 41 kDa
Purified recombinant fragment of human CD191 (AA: extra mix) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD191 is a Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses. Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine. For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF-alpha and leukotriene B4. Also mediates monocyte migration upon CXCL4 binding. Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway[1][2][3].
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Subcellular Localization
Cell membrane; Multi-pass membrane protein
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Expression
Tissue_specificity:Widely expressed in different hematopoietic cells
Induction:Up-regulated by CREB3 -
Subunit
Interacts with CREB3 (PubMed:15001559). Interacts with CCL3 (PubMed:15905581). Interacts with CCL15 (PubMed:15905581, PubMed:34949837). Interacts with CCL23 (PubMed:15905581). Interacts with GNAI1 (PubMed:34949837). Interacts with PF4/CXCL4 (PubMed:29930254)
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SwissProt ID
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Synonyms
CCR1; CKR1; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1
Documentation
References
[2]. Berahovich RD, et al. Proteolytic activation of alternative CCR1 ligands in inflammation. J Immunol. 2005 Jun 1;174(11):7341-51. [Content Brief]
[3]. Fox JM, et al. CXCL4/Platelet Factor 4 is an agonist of CCR1 and drives human monocyte migration. Sci Rep. 2018 Jun 21;8(1):9466. [Content Brief]
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