CD191 Antibody (YA3957)(PBS only)

Cat. No.: HY-P84260A: Data Sheet User Guide for Antibodies
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CD191 Antibody (YA3957) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD191.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

CD191 Antibody (YA3957) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD191.

Host

Mouse

Molecular Weight

Predicted band size: 41 kDa;

Observed band size: 41 kDa0

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

P32246

Gene ID

1230 [NCBI]

Immunogen

Purified recombinant fragment of human CD191 (AA: extra mix) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:2000
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses (PubMed:14991608). Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine (PubMed:15905581). For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF-alpha and leukotriene B4 (By similarity). Also mediates monocyte migration upon CXCL4 binding (PubMed:29930254). Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway (By similarity)

Subcellular Localization：Cell membrane; Multi-pass membrane protein

Expression：
Tissue_specificity:Widely expressed in different hematopoietic cells

Induction:Up-regulated by CREB3

Subunit：Interacts with CREB3 (PubMed:15001559). Interacts with CCL3 (PubMed:15905581). Interacts with CCL15 (PubMed:15905581, PubMed:34949837). Interacts with CCL23 (PubMed:15905581). Interacts with GNAI1 (PubMed:34949837). Interacts with PF4/CXCL4 (PubMed:29930254)

Synonyms

CCR1; CKR1; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1

Documentation

User Guide for Antibodies (1077 KB)