CIAO2A - cytosolic iron-sulfur assembly component 2A Gene
Also Known as CIA2A; FAM96A
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 84191
Summary
Predicted to enable metal ion binding activity. Involved in iron-sulfur cluster assembly and protein maturation. Located in cytosol and nucleoplasm. Part of cytosolic [4Fe-4S] assembly targeting complex. [provided by Alliance of Genome Resources, Jun 2026]
Ubiquitous expression in liver (RPKM 13.5), duodenum (RPKM 11.9) and 25 other tissues.
CIAO2A Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001014812.3 | NP_001014812.1 | cytosolic iron-sulfur assembly component 2A isoform b |
| NM_001289108.2 | NP_001276037.1 | cytosolic iron-sulfur assembly component 2A isoform b |
| NM_032231.7 | NP_115607.1 | cytosolic iron-sulfur assembly component 2A isoform a |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16189514 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in iron-sulfur cluster assembly |
IMP
IMP: Inferred from mutant phenotype
|
23891004 | GOA |
| involved in protein maturation by iron-sulfur cluster transfer |
IMP
IMP: Inferred from mutant phenotype
|
23891004 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of cytosolic [4Fe-4S] assembly targeting complex |
IDA
IDA: Inferred from direct assay
|
23891004 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
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CIAO2A Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CIAO2A | Q9H5X1 | TNFRSF10D | Homo sapiens | Q9UBN6 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | TNFRSF10D | Homo sapiens | Q9UBN6 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | TNFRSF10D | Homo sapiens | Q9UBN6 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | MEST | Homo sapiens | Q5EB52 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | MEST | Homo sapiens | Q5EB52 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | CMTM6 | Homo sapiens | Q9NX76 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | CMTM6 | Homo sapiens | Q9NX76 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | CMTM6 | Homo sapiens | Q9NX76 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | TMED8 | Homo sapiens | Q6PL24 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | TMED8 | Homo sapiens | Q6PL24 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | DGAT2L6 | Homo sapiens | Q6ZPD8 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | DGAT2L6 | Homo sapiens | Q6ZPD8 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | SIN3A | Homo sapiens | H3BQL7 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | SIN3A | Homo sapiens | H3BQL7 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | GJA8 | Homo sapiens | P48165 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | GJA8 | Homo sapiens | P48165 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | RHBDD2 | Homo sapiens | Q6NTF9-3 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | RHBDD2 | Homo sapiens | Q6NTF9-3 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | GSC2 | Homo sapiens | O15499 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | GSC2 | Homo sapiens | O15499 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | KCNIP1 | Homo sapiens | Q9NZI2-2 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | KCNIP1 | Homo sapiens | Q9NZI2-2 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | KCNIP1 | Homo sapiens | Q9NZI2-2 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | SETD4 | Homo sapiens | Q9NVD3-4 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | SETD4 | Homo sapiens | Q9NVD3-4 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | SETD4 | Homo sapiens | Q9NVD3-4 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | PRAF2 | Homo sapiens | O60831 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | PRAF2 | Homo sapiens | O60831 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | LIME1 | Homo sapiens | Q9H400 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | LIME1 | Homo sapiens | Q9H400 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | FKBP7 | Homo sapiens | Q9Y680 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | FKBP7 | Homo sapiens | Q9Y680 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | FKBP7 | Homo sapiens | Q9Y680 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | DERL1 | Homo sapiens | Q9BUN8 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | DERL1 | Homo sapiens | Q9BUN8 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | CREB3L1 | Homo sapiens | Q96BA8 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | CREB3L1 | Homo sapiens | Q96BA8 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | CIAO1 | Homo sapiens | O76071 | 33961781 | |
|
Intra
|
CIAO2A | Q9H5X1 | CIAO1 | Homo sapiens | O76071 | 32222833 | |
|
Intra
|
CIAO2A | Q9H5X1 | CIAO1 | Homo sapiens | O76071 | 32222833 | |
|
Intra
|
CIAO2A | Q9H5X1 | CIAO1 | Homo sapiens | O76071 | 25416956 | |
|
Intra
|
CIAO2A | Q9H5X1 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | EBAG9 | Homo sapiens | O00559 | 32296183 | |
|
Intra
|
CIAO2A | Q9H5X1 | EBAG9 | Homo sapiens | O00559 | 32296183 |
Cross: Cross-species interaction
Intra: Intraspecies interaction