MEST - mesoderm specific transcript Gene

Also Known as PEG1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4232

About MEST

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:130,486,175-130,506,465 (from NCBI)

This gene has 17 transcripts (splice variants), 242 orthologues and 12 paralogues. Biased expression in placenta (RPKM 292.2), fat (RPKM 48.4) and 6 other tissues.

Summary

This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of Cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. [provided by RefSeq, Dec 2011]

MEST Products (6)

mRNA	Protein	Name
NM_001253900.1	NP_001240829.1	mesoderm-specific transcript homolog protein isoform c
NM_001253901.1	NP_001240830.1	mesoderm-specific transcript homolog protein isoform d precursor
NM_001253902.1	NP_001240831.1	mesoderm-specific transcript homolog protein isoform d precursor
NM_002402.4	NP_002393.2	mesoderm-specific transcript homolog protein isoform a
NM_177524.2	NP_803490.1	mesoderm-specific transcript homolog protein isoform b precursor
NM_177525.2	NP_803491.1	mesoderm-specific transcript homolog protein isoform b precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MEST Protein Structure

Abhydrolase_6

0
100
200
300
335 a.a.

Protein Preferred Names	Protein Names
mesoderm-specific transcript homolog protein	paternally-expressed gene 1 protein

MEST Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MEST	Q5EB52	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Array	32296183
Intra	MEST	Q5EB52	RNF19B	Homo sapiens	Q6ZMZ0	Validated Y2H	32296183
Intra	MEST	Q5EB52	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Prey Pooling	32296183
Intra	MEST	Q5EB52	LIME1	Homo sapiens	Q9H400	Y2H Array	32296183
Intra	MEST	Q5EB52	LIME1	Homo sapiens	Q9H400	Validated Y2H	32296183
Intra	MEST	Q5EB52	LIME1	Homo sapiens	Q9H400	Y2H Prey Pooling	32296183
Intra	MEST	Q5EB52	CIDEB	Homo sapiens	Q9UHD4	Validated Y2H	32296183
Intra	MEST	Q5EB52	CIDEB	Homo sapiens	Q9UHD4	Y2H Array	32296183
Intra	MEST	Q5EB52	CIDEB	Homo sapiens	Q9UHD4	Y2H Prey Pooling	32296183
Intra	MEST	Q5EB52	C6orf47	Homo sapiens	O95873	Y2H Prey Pooling	32296183
Intra	MEST	Q5EB52	C6orf47	Homo sapiens	O95873	Y2H Array	32296183
Intra	MEST	Q5EB52	CIAO2A	Homo sapiens	Q9H5X1	Validated Y2H	32296183
Intra	MEST	Q5EB52	GAD2	Homo sapiens	Q05329	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Childhood-Onset Schizophrenia	Childhood Schizophrenia Schizophrenia, Childhood
Adult Cystic Nephroma	Multilocular Cystic Nephroma, Mixed Epithelial Stromal Tumour And Renal Epithelial Stromal Tumour
Mixed Epithelial Stromal Tumour
Kidney Cortex Disease
Transient Neonatal Diabetes Mellitus	Diabetes Mellitus, Transient Neonatal Tndm Chromosome 6-Associated Transient Diabetes Mellitus Dmtn Diabetes Mellitus, 6q24-Related Transient Neonatal Tndm1 Neonatal Diabetes Mellitus, Transient Tndm -[Transient Neonatal Diabetes Mellitus]
Mulchandani-Bhoj-Conlin Syndrome	MBCS Maternal Uniparental Disomy Of Chromosome 20 Maternal Upd(20) Upd(20)Mat Uniparental Disomy, Maternal, Chromosome 20
Hypersensitivity Vasculitis	Cutaneous Small Vessel Vasculitis Hypersensitivity Angiitis Cutaneous Leukocytoclastic Vasculitis Leukocytoclastic Angiitis Vasculitis, Leukocytoclastic, Cutaneous Leukocytoclastic Vasculitis Cutaneous Leukocytoclastic Angiitis Cutaneous Hypersensitivity Vasculitis Vasculitis Hypersensitivity Drug Induced Cutaneous Vasculitis Allergic Vasculitis
Silver-Russell Syndrome 1	Silver-Russell Syndrome Russell-Silver Syndrome Silver-Russell Dwarfism Rss SRS1 Srs Silver Russell Dwarfism Russell Silver Syndrome Silver Russell Syndrome
Henoch-Schoenlein Purpura	Henoch-Schonlein Purpura Iga Vasculitis Allergic Purpura Anaphylactoid Purpura Rheumatoid Purpura Immunoglobulin A Vasculitis Vascular Purpura Purpura Rheumatica Henoch-Schönlein Purpura Autoimmune Purpura Henoch-Schnlein Purpura Henoch-Sch@Nlein Purpura Henoch-Scholein Purpura Purpura, Autoimmune Henoch Schonlein Purpura Immunoglobulin-A Vasculitis Purpura, Schonlein-Henoch Purpura, Schönlein-Henoch Hsp - Schönlein-Henoch Purpura
Hypersensitivity Reaction Type Iii Disease	Immune Complex Diseases Immune Complex Disease Type Iii Hypersensitivity Reaction Disease
Rapidly Progressive Glomerulonephritis	Glomerulonephritis Rapidly Progressive Idiopathic Crescentic Glomerulonephritis
Temple Syndrome	Uniparental Disomy, Maternal, Chromosome 14 Temple Syndrome Due To Paternal 14q32.2 Microdeletion Paternal Del(14)(Q32.2) Temple Syndrome Due To Paternal 14q32.2 Hypomethylation Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14 Upd(14)Mat
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Spastic Paraplegia 17, Autosomal Dominant	Silver Syndrome SPG17 Silver Spastic Paraplegia Syndrome Spastic Paraplegia With Amyotrophy Of Hands And Feet Hereditary Spastic Paraplegia 17 Autosomal Dominant Spastic Paraplegia Type 17 Spastic Paraplegia 17 Spastic Paraplegia-Amyotrophy Of Hands And Feet Autosomal Dominant Spastic Paraplegia 17 Dhmn5b Distal Hereditary Motor Neuropathy Type 5b Paraplegia, Spastic, Autosomal Dominant, Type 17 Russell-Silver Syndrome Neuronopathy, Distal Hereditary Motor, Type Vb
Iga Glomerulonephritis	Iga Nephropathy Glomerulonephritis, Iga Berger'S Iga Or Igg Nephropathy Focal Glomerulonephritis Primary Iga Nephropathy Segmental Glomerulonephritis Berger Disease Berger'S Disease Igan Nephritis, Iga Type Nephropathy Iga Glomerulonephritis Focal Iga Nephropathy, Susceptibility To Primary Immunoglobulin A Nephropathy
Kagami-Ogata Syndrome	Paternal Uniparental Disomy Of Chromosome 14 Uniparental Disomy, Paternal, Chromosome 14 Kos Mca Due To 14q32.2 Maternally Expressed Gene Defect Paternal Uniparental Disomy 14 Kagami-Ogata Syndrome Due To Maternal 14q32.2 Microdeletion Maternal Del(14)(Q32.2) Maternal Monosomy 14q32.2 Kagami-Ogata Syndrome Due To Maternal 14q32.2 Hypermethylation Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14 Upd(14)Pat
Pseudohypoparathyroidism, Type Ib	Pseudohypoparathyroidism Type 1b PHP1B Pseudohypoparathyroidism Ib Pseudohypoparathyroidism Type Ib Php Ib Pseudohypoparathyroidism 1b
Beckwith-Wiedemann Syndrome	Wiedemann-Beckwith Syndrome BWS Exomphalos-Macroglossia-Gigantism Syndrome Emg Syndrome Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation Emg Abnormality Wbs Exomphalos Macroglossia Gigantism Syndrome Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation Macroglossia Exomphalos Gigantism
Gestational Trophoblastic Neoplasm	Hydatidiform Mole Molar Pregnancy Gestational Trophoblastic Neoplasia Gestational Trophoblastic Tumor Gtn Gestational Trophoblastic Disease Gestational Trophoblastic Neoplasms Hydatidiform Mole, Recurrent, 1 Hydatidiform Mole Benign Trophoblastic Disease Trophoblastic Disease Nos Trophoblastic Disorder Vesicular Mole Nos Vesicular Mole Hydatidiform Mole Nos
Adult Syndrome	Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome Acro Dermato Ungual Lacrimal Tooth Syndrome Pigment Anomaly-Ectrodactyly-Hypodontia Syndrome Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome Adult
Prader-Willi Syndrome	Prader-Labhart-Willi Syndrome PWS Willi-Prader Syndrome Prader-Willi Syndrome Due To Translocation Prader-Willi Syndrome Due To Imprinting Mutation Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15 Prader Willi Syndrome Upd(15)Mat
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-14336A	SB 271046 Hydrochloride	Antagonist	99.93%	Unkown
HY-125928	AA43279	Inhibitor	99.80%	Unkown
HY-RS08344	MEST Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18950	Mest Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25440	Mest Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MEST	VGNC	VGNC:43165
Macaca mulatta	MEST	VGNC	VGNC:74707
Rattus norvegicus	MEST	RGD	RGD:1594589
Mus musculus	MEST	MGD	MGI:96968
Bos taurus	MEST	VGNC	VGNC:31393
Felis catus	MEST	VGNC	VGNC:97504
Others	MEST	NCBI